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Updated: Jan 22, 2026

Triplet Fusion Upconversion Nanocapsule Synthesis
Published on: September 7, 2022
レドックス応答性ポリウレタンナノカプセルの合成、低分子ドラッグデリバリー、およびヒト白血病K562細胞に対する抗腫瘍評価
Na Shi1, Mengting Liu1, Dandan He1
1Guizhou Engineering Laboratory for Synthetic Drugs, College of Pharmacy, Guizhou University, Guiyang, 550025, People's Republic of China.
Abstract:
High concentrations of glutathione (GSH) in the tumor microenvironment (TME) represent a promising target for the development of polyurethane (PU)-based redox-responsive drug delivery systems. A series of 3-indolopyrazole acetamide derivatives were designed and synthesized in this study. The anti-proliferative activities of these compounds were evaluated in tumor cell lines, and the small molecule S11 (IC50 = 2.64 μM) was identified as a potent inhibitor of human chronic myeloid leukemia K562 cells. To overcome the challenges of poor solubility and limited stability associated with the hydrophobic small molecule S11, polyurethane nanocapsules containing disulfide bonds (S-S) were innovatively synthesized. Subsequently, drug-loaded polyurethane nanocapsules (S11-1) were synthesized via interfacial polymerization. In vitro experimental results indicated that these nanocapsules exhibit enhanced drug release performance compared to free S11, with a GSH-responsive release mechanism. Furthermore, S11-1 effectively promotes K562 cell apoptosis, elevates intracellular Reactive Oxygen Species (ROS) levels, and induces mitochondrial membrane potential depolarization (MMP). Overall, S11-1 demonstrates considerable potential in enhancing drug delivery efficiency, improving targeting precision, and modulating biological activity.
関連する概念動画
Redox Reactions
Redox Reactions
Balancing Redox Equations
Synthesis and Decomposition Reactions
Dehydration Synthesis
Dehydration synthesis (also called a condensation reaction) is the chemical process in which two molecules covalently link together to form a new molecule, along with the release of a water molecule. Many physiologically important compounds form by dehydration synthesis reactions, such as complex carbohydrates, proteins, DNA, and RNA.
Synthesis of carbohydrates
Sugar molecules are covalently linked together by dehydration synthesis. During the reaction, the hydroxyl (-OH) group from...
Redox Equilibria: Overview

