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Updated: Jan 23, 2026

An Anatomical Study of Nerves at Risk During Minimally Invasive Hallux Valgus Surgery

An Anatomical Study of Nerves at Risk During Minimally Invasive Hallux Valgus Surgery

Published on: February 17, 2018

待機的低侵襲大腸手術における連続創部浸潤対プラセボ（CIMICS）：ランダム化比較試験の試験プロトコル

Sofie Glazemakers^1,2, Stijn H J Ketelaers¹, Harm J Scholten³

¹Department of Surgery, Catharina Hospital, Eindhoven, the Netherlands.

|January 21, 2026

要旨

Background:

Enhanced Recovery After Surgery (ERAS) programs emphasize multimodal analgesia to minimize opioid use and improve patient outcomes. Continuous wound infiltration (CWI) with local analgesic is a promising adjunct to multimodal analgesia. However, its benefits in minimally invasive procedures and ERAS-adherent care remain unknown. This trial investigates whether the addition of CWI to standard ERAS care improves postoperative recovery following minimally invasive colorectal surgery.

Methods:

In this single-centre, blinded, randomised controlled trial, 192 eligible patients are randomised to receive either a CWI system with bupivacaine 0.125% (the interventional arm), or a placebo CWI with physiological saline (the control arm). All patients receive standardized ERAS perioperative care with multimodal analgesia. The primary outcome is the Quality of Recovery-15 score (QoR-15NL) on postoperative day 2. Secondary outcomes include QoR-15NL and pain scores (postoperative days 1-5), opioid consumption, length of hospital stay, key functional recovery milestones, and 90-day postoperative complications.

Discussion:

This will be the first randomised controlled trial evaluating the effect of CWI within minimally invasive and ERAS-adherent colorectal surgery. The trial findings may improve evidence-based perioperative care guidelines and enhance postoperative multimodal analgesia.

キーワード:

連続創部浸潤低侵襲大腸手術術後回復強化外科多角的鎮痛ランダム化比較試験

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