多発性硬化症の治療候補としてバイサントを特定するインシリコスクリーニングと前臨床検証
Nadjet Gacem1, Svetlana Bezukladova2, Farina Windener3
1Paris Brain Institute - Institut du Cerveau (ICM), Sorbonne Université, Inserm, CNRS, Hôpital de la Pitié-Salpêtrière, AP-HP, 75013 Paris, France.
Science translational medicine
|January 21, 2026
まとめ
多発性硬化症(MS)の新しい薬物発見が有望視されている。ヒスタミン受容体H3拮抗薬であるバイサントは、前臨床モデルで再髄鞘形成と神経保護を実証し、進行性MS治療に希望をもたらしている。
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