アジュバントフリーの生体高分子粒子がチクングニアウイルス表面を模倣して防御免疫を誘導する
Nivethika Sivakumaran1, Joseph Freitas2, Shuxiong Chen1
1Centre for Cell Factories and Biopolymers, Griffith University, Nathan, Australia; Institute for Biomedicine and Glycomics, Griffith University, Gold Coast, Australia.
Biomaterials
|January 21, 2026
まとめ
エンジニアリングされた細菌(大腸菌)を用いた新規チクングニアウイルス(CHIKV)ワクチンは、ウイルスタンパク質でコーティングされた安全で費用対効果の高い生体高分子粒子を生成した。このワクチンは、アジュバントなしでマウスに強力な免疫と防御を誘導し、現在の選択肢に代わる有望な代替手段を提供する。
関連する概念動画
What is the Immune System?
127.1K
Overview
127.1K
What are Viruses?
127.8K
Overview
127.8K
Factors Affecting Dissolution: Particle Size and Effective Surface Area
1.6K
Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
1.6K
Subatomic Particles
112.4K
Dalton was only partially correct about the particles that make up matter. All matter is composed of atoms, and atoms are composed of three smaller subatomic particles: protons, neutrons, and electrons. These three particles account for the mass and the charge of an atom.
112.4K
Zones of Protection
770
In power systems, the entire setup is divided into protective zones to isolate faults and protect the rest of the network. These zones include generators, transformers, buses, transmission lines, distribution lines, and motors. Each zone can be visualized as a separate room in a house, with each room protected by its own circuit breaker.
Protective zones are defined by closed dashed lines, containing one or more components. A key characteristic of these zones is the strategic placement of...
Protective zones are defined by closed dashed lines, containing one or more components. A key characteristic of these zones is the strategic placement of...
770
Protection of Alcohols
8.0K
This lesson delves into the concept of protection and deprotection of a functional group fundamental to synthetic organic chemistry. These phenomena are explained in the context of aliphatic and aromatic alcohols.
Protection
It defines a protecting group as the masking agent to make the more reactive species inert to a given set of conditions. This concept is depicted via the illustration of liquid flow through different outlets in an assembly of pipes. The analogy helps to understand the role...
Protection
It defines a protecting group as the masking agent to make the more reactive species inert to a given set of conditions. This concept is depicted via the illustration of liquid flow through different outlets in an assembly of pipes. The analogy helps to understand the role...
8.0K


