睡眠時無呼吸症候群と物質使用:メタアナリシス
Sibylle Mauries1, Benjamin Rolland2, Justine Frija-Masson3
1Département de Psychiatrie et D'addictologie, AP-HP, GHU Paris Nord, DMU Neurosciences, Hôpital Bichat - Claude Bernard, F-75018, Paris, France.
Sleep medicine reviews
|January 21, 2026
まとめ
このメタアナリシスでは、アルコールおよびオピオイドの使用が、睡眠時無呼吸症の重症度を示す無呼吸低呼吸指数(AHI)を有意に増加させることが明らかになった。依存症治療の転帰を改善するためには、薬物使用者における睡眠時無呼吸症候群の診断が極めて重要である。
科学分野:
- 睡眠医学;依存症精神医学;公衆衛生
背景:
- 睡眠時無呼吸症候群と物質使用障害(SUD)は、双方向的かつ負の関係を示す。;閉塞性睡眠時無呼吸症候群(OSA)は、SUDを有する個人において特に一般的である。
研究 の 目的:
- 一般的な物質(アルコール、タバコ、カンナビノイド、オピオイド、コカイン)が無呼吸低呼吸指数(AHI)に及ぼす影響をメタアナリシスで評価する。;物質使用者と非使用者間のAHIスコアを比較する。
主な方法:
- PubMedを用いた系統的文献検索。;メタアナリシスに28件の研究を含める。;物質使用者と非使用者間の平均AHIスコアの比較。
主要な成果:
- アルコール使用者はAHIが高い(SMD:0.46、p < 0.001)。;オピオイド使用者は中枢性睡眠時無呼吸症の有病率が高い(SMD:0.44、p < 0.001)。;タバコ使用者はAHIが増加するが、統計的に有意ではない。カンナビノイドおよびコカイン使用に関するデータは限定的である。
結論:
- 睡眠時無呼吸症候群の診断と管理は、物質使用患者にとって不可欠である。;効果的な睡眠時無呼吸症候群の治療は、依存症の予後を改善できる。;併存する睡眠時無呼吸症候群とSUDには、個別化された治療アプローチが必要である。
関連する概念動画
Sleep Apnea
500
Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...
The condition is more prevalent among...
500
Substance Use Disorders Affecting Sleep
407
Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...
Understanding the concepts of physical dependence,...
407
Insufficient Sleep and Sleep Deprivation
855
Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
Sleep deprivation is a more severe form of sleep loss...
Sleep deprivation is a more severe form of sleep loss...
855
Deleterious Substances in Aggregate
540
Deleterious substances in aggregates can be detrimental to the quality and durability of concrete. These substances include organic impurities like loam, which interfere with cement hydration and are usually present in the sand. These prevent a good bond between aggregate and cement paste. Organic impurities can be detected using the colorimetric test, where the darkness of a solution after agitation indicates the level of organic content.
Another type of impurity is clay and fine material that...
Another type of impurity is clay and fine material that...
540
Directing Effect of Substituents: meta-Directing Groups
5.8K
Substituents on the benzene ring that direct an incoming electrophile to undergo substitution at the meta position are called meta directors. All meta directors either have a positive charge on the atom directly bonded to the ring or a partial positive charge. These groups function by withdrawing electrons from the ring through inductive and resonance effects. Consider the carbocation intermediates formed upon the addition of an electrophile on nitrobenzene at the...
5.8K
Stages of Sleep
1.3K
Sleep progresses through distinct stages, each characterized by specific brain wave patterns and physiological responses ranging from wakefulness to stages of non-rapid eye movement, known as non-REM, to rapid eye movement, referred to as REM. Understanding these stages helps in recognizing how sleep supports various bodily and cognitive functions.
Before sleep begins, in wakefulness, the brain exhibits primarily beta waves, which are high in frequency and low in amplitude, indicating alertness...
Before sleep begins, in wakefulness, the brain exhibits primarily beta waves, which are high in frequency and low in amplitude, indicating alertness...
1.3K


