近視進行抑制における末梢デフォーカスレンズと単焦点レンズの臨床的有効性

Fabian Schibli^1,2, Anja Palmowski-Wolfe^1,2

¹Medical Faculty, University of Basel, Switzerland.

Klinische Monatsblatter fur Augenheilkunde

|January 21, 2026

まとめ

末梢デフォーカスレンズ（PDL）は、実世界の設定で近視進行を大幅に抑制し、管理された試験の結果を確認します。PDLは、近視患者の軸性伸長を管理するための効果的な臨床的選択肢を提供します。

科学分野:

眼科学; 視能矯正学; 臨床研究

背景:

近視管理のための末梢デフォーカスレンズ（PDL）の実際的な有効性を調査すること。; PDLの有効性が臨床試験から標準的な実践に移行するかどうかを評価すること。

研究の目的:

臨床環境における近視管理のためのPDLと単焦点（SV）レンズの効果を評価すること。; PDLまたはSVレンズで治療された近視患者の軸性伸長および等価球面度数の変化を分析すること。

主な方法:

バーゼル大学眼科病院（2019-2024）の臨床記録の遡及的分析。; 適格基準：近視診断、少なくとも3回の眼軸長測定、およびPDLまたはSVレンズの排他的使用。; 独立t検定（有意水準p < 0.05）を用いた軸性伸長および等価球面度数の比較。

主要な成果:

PDLは、両眼ともに6ヶ月、12ヶ月、18ヶ月でSVレンズと比較して軸性伸長を有意に抑制しました。; 18ヶ月で、軸性伸長の有意差が観察されました（両眼ともp < 0.001）。; 等価球面度数に一貫した傾向は見られず、18ヶ月で右眼のみに有意差が見られました（p = 0.044）。

結論:

PDLレンズは、実際の臨床現場において近視性軸性伸長を抑制する上で有意な有効性を示します。; この結果は、以前の管理された試験の結果を支持し、近視進行管理のための効果的なツールとしてのPDLを検証します。; この研究は、近視進行管理のためのPDLの臨床導入を支持します。

キーワード:

近視進行末梢デフォーカスレンズ単焦点レンズ軸性伸長近視管理

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