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Updated: Jan 23, 2026

Surgical Bone Implantation Technique for Rat Tibia Models of Diabetes and Osteoporosis

Surgical Bone Implantation Technique for Rat Tibia Models of Diabetes and Osteoporosis

Published on: July 5, 2024

糖尿病性骨粗鬆症における代謝調節不全を標的とした磁場による骨リモデリングの調節

Chunqin Li¹, Xige Dong¹, Mengxu Sun¹

¹Key Laboratory for Space Bioscience and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi'an, Shaanxi 710072, China.

Progress in biophysics and molecular biology

|January 21, 2026

Abstract:

Diabetes mellitus, a chronic metabolic disorder associated with high risk of cardiovascular disease, kidney disease, neuropathy and bone disorder, has emerged as a globally epidemic public health issue. Osteoporosis, the most common bone disease in middle-aged and elderly populations, demonstrates a particularly high prevalence in individuals with diabetes mellitus. This correlation underscores the urgent need to develop innovative strategies to improve the quality of life for patients with diabetic osteoporosis. Magnetic field-based physical therapy, a non-invasive therapeutic modality, presents distinct advantages over conventional treatments. Recent advances in biomagnetic research have unveiled novel biological and therapeutic effects of magnetic fields, with accumulating evidence supporting their potential clinical applications in bone-related disorders. This review critically examines the mechanistic links between diabetes mellitus and the deterioration of bone health, the therapeutic effects of both dynamic and static magnetic fields on diabetes-associated complications, with a specific focus on skeletal outcomes, and the prospective applications of magnetic fields intervention for maintaining bone health in diabetes mellitus. Ultimately, this review aims to propose novel therapeutic strategies for managing osteoporosis in diabetes mellitus through magnetic approaches.

キーワード:

磁場の生物学的効果骨の健康糖尿病糖尿病性骨粗鬆症磁場

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