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Updated: Jan 23, 2026

Deep Learning-Based Segmentation of Cryo-Electron Tomograms

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ゼラレノン加水分解酵素およびキシラナーゼの熱安定性を向上させるマルチ目的最適化によるゼロショット深層学習

Fan Wu¹, Rui Wu¹, Linghui Chen²

¹Department of Rheumatology and Immunology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, Hefei National Research Center for Physical Sciences at the Microscale, Center for Advanced Interdisciplinary Science and Biomedicine of IHM, University of Science and Technology of China, Hefei, Anhui, 230001, China; MOE Key Laboratory for Membraneless Organelles and Cellular Dynamics, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui 230027, China.

New biotechnology

|January 21, 2026

まとめ

シーケンスと構造の深層学習モデルを組み合わせることで、熱安定性が向上し活性が維持されたマルチサイト酵素変異体を効率的に生成します。この統合アプローチは、工業用酵素開発における個々の方法の限界を克服します。

キーワード:

深層学習酵素活性酵素熱安定性タンパク質配列設計

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Creating Objects and Object Categories for Studying Perception and Perceptual Learning

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