Drosophilaに対する小麦由来微生物曝露は、模擬微小重力下での免疫と生存率を向上させる

Letian Chen¹, Shijing Wang¹, Chuanmeng Cai¹

¹Key Laboratory of Biomechanics and Mechanobiology (Beihang University), Ministry of Education, Key Laboratory of Innovation and Transformation of Advanced Medical Devices, Ministry of Industry and Information Technology, National Medical Innovation Platform for Industry-Education Integration in Advanced Medical Devices (Interdiscipline of Medicine and Engineering), School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China; Innovation Center for Medical Engineering &Engineering Medicine, Hangzhou International Innovation Institute, Beihang University, Hangzhou 311115, China; Institute of Environmental Biology and Life Support Technology, School of Biological Science and Medical Engineering, Beihang University, Beijing, China.

Life sciences in space research

|January 21, 2026

まとめ

小麦由来微生物は、模擬微小重力下でのショウジョウバエの免疫力と生存率を向上させる。この研究は、長期間の宇宙ミッションのための宇宙飛行士の免疫力を高めるための新しい戦略を提供する。

科学分野:

微生物学、宇宙生物学、免疫学

背景:

微小重力は宇宙飛行士の免疫系を損ない、長期間の宇宙滞在中の感染リスクを高める。植物由来の微生物は免疫増強の潜在的な解決策を提供するが、その有効性とメカニズムについてはさらなる調査が必要である。

研究の目的:

模擬微小重力（SMG）下でのショウジョウバエの免疫力を強化するために小麦由来微生物を使用することの実現可能性とメカニズムを調査すること。

主な方法:

SMG下での小麦とショウジョウバエの共培養。ショウジョウバエの免疫の変化を調べるためのマルチオミクス解析。宿主における微生物の移動と定着の確認。

主要な成果:

小麦由来微生物はショウジョウバエの生存率と免疫力を著しく改善した。MassiliaやLongimicrobiumなどの免疫関連微生物の濃縮が観察された。Tollシグナル伝達およびグルタチオン代謝経路における主要な免疫遺伝子のアップレギュレーションにより、免疫物質の分泌が強化された。

結論:

小麦由来微生物はショウジョウバエに効果的に移動・定着し、免疫力を強化し、免疫機能障害を改善することができる。本研究は、宇宙飛行士の免疫力を強化するための革新的な戦略と、宇宙探査における生命維持システムのための理論的根拠を提供する。

キーワード:

ショウジョウバエ免疫模擬微小重力小麦由来微生物

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