27歳男性に重度の掻痒感を伴って発症した自己免疫性肝炎

Autoimmune hepatitis (AIH) is a chronic immune-mediated liver disorder characterized by progressive hepatocellular inflammation and elevated autoantibodies. Although most patients present with jaundice, fatigue, or nonspecific hepatic symptoms, pruritus as the primary complaint is uncommon, especially in the absence of overt cholestasis. We report a case of a 27-year-old male presenting with severe generalized pruritus who was ultimately diagnosed with AIH. Laboratory evaluation revealed a hepatocellular injury pattern, strongly positive autoimmune serology, and elevated IgG levels, consistent with AIH. High-dose prednisolone therapy led to marked symptomatic improvement and rapid biochemical normalization. This case highlights pruritus as an uncommon but important presentation of AIH and underscores the need to consider AIH in patients with persistent, unexplained pruritus.