ROS応答性多機能DCSベースミセルヒドロゲルによる術後黒色腫再発抑制と創傷治癒促進の同時達成

Delayed healing of post-resection melanoma wounds is prone to induce tumor recurrence. Therefore, postoperative wound management for tumor resection needs to concurrently address anti-cancer activity and wound healing promotion. In this study, a multifunctional micelle hydrogel (AB@MH) was fabricated by integrating reactive oxygen species (ROS)-responsive nanomicelles, which was co-loaded with apigenin and BMS-202, into a dodecyl-modified chitosan (DCS)-based hydrogel via Schiff base linkages and hydrogen bonding interactions for post-resection melanoma therapy. This micelle hydrogel enabled ROS-triggered drug release, thereby minimizing systemic toxicity. More importantly, the released apigenin exerted selective cytotoxicity against tumor cells and bacteria while inducing immunogenic cell death (ICD). When combined with co-released BMS-202, the formulation enhanced anti-tumor efficacy without harming normal tissue cells. Moreover, AB@MH was fabricated via a straightforward, crosslinker-free method, ensuring excellent biocompatibility and effective wound healing promotion. In the melanoma resection model, the AB@MH group markedly suppressed tumor recurrence and accelerated wound repair. This work successfully integrates post-resection antitumor therapy and wound healing enhancement, achieving both safety and efficacy in postoperative cancer therapy.