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Translesion DNA Polymerases02:10

Translesion DNA Polymerases

11.1K
Translesion (TLS) polymerases rescue stalled DNA polymerases at sites of damaged bases by replacing the replicative polymerase and installing a nucleotide across the damaged site. Doing so, TLS allows additional time for the cell to repair the damage before resuming regular DNA replication.
TLS polymerases are found in all three domains of life - archaea, bacteria, and eukaryotes. Of the different classes of TLS polymerases, members of the Y family are fitted with specialized structures that...
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Nucleotide Excision Repair01:08

Nucleotide Excision Repair

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Overview
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Restarting Stalled Replication Forks02:37

Restarting Stalled Replication Forks

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DNA replication is initiated at sites containing predefined DNA sequences known as origins of replication. DNA is unwound at these sites by the minichromosome maintenance (MCM) helicase and other factors such as Cdc45 and the associated GINS complex.The unwound single strands are protected by replication protein A (RPA) until DNA polymerase starts synthesizing DNA at the 5’ end of the strand in the same direction as the replication fork. To prevent the replication fork from falling apart,...
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陰茎上皮内病変

Hongzhi Xu1, Jasreman Dhillon

  • 1Department of Pathology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL.

Advances in anatomic pathology
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まとめ
この要約は機械生成です。

陰茎上皮内病変には、尖圭コンジローマおよび陰茎上皮内腫瘍（PeIN）が含まれる。これらの病変は、HPV関連またはHPV独立型に分類され、それぞれ異なる特徴と関連する危険因子を持つ。

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尖圭コンジローマ乳房外パジェット病黒色腫 in situ陰茎上皮内腫瘍

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