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Updated: Jan 23, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives

Published on: January 19, 2016

アニリンのTEMPO駆動ラジカル機構を介したメカノケミカルトリガー脱アミノハロゲン化

Pan Gao¹, Bin Xu¹, Xin Zhang¹

¹College of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, China.

Organic letters

|January 22, 2026

Abstract:

Under ball-milling, continuous mechanical energy enables a TEMPO-mediated single-electron process, while inexpensive ferric nitrate serves as the nitrogen source for in situ diazotization. This method rapidly converts anilines into aryl halides with broad functional-group tolerance, avoiding hazardous diazonium salts, external heating, and bulk solvents. The approach improves operational simplicity, atom economy, and sustainability, highlighting the power of mechanochemistry to promote redox-driven transformations and providing a practical alternative to conventional solution-phase halogenation.

キーワード:

メカノケミストリーアニリンハロゲン化 TEMPO 持続可能な合成

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Free Radicals in Chemical Biology: from Chemical Behavior to Biomarker Development

Free Radicals in Chemical Biology: from Chemical Behavior to Biomarker Development

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In Vitro Method to Control Concentrations of Halogenated Gases in Cultured Alveolar Epithelial Cells

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