フィンランドからの研究:国外で入院した小児における多剤耐性菌の定着
Hilda A F Mäkinen1,2,3, Mikael J Kajova1,2,3,4, Tamim S B Khawaja1,2,3,4
1FIMAR, Finnish Multidisciplinary Centre of Excellence in Antimicrobial Resistance Research, University of Helsinki, Helsinki, Finland.
Journal of travel medicine
|January 22, 2026
まとめ
国外で入院した小児は、多剤耐性菌(MDRO)を頻繁に獲得しており、特に低中所得国では定着率が増加している。低中所得国からの帰国小児、特に最近抗生物質を使用した小児のスクリーニングが推奨される。
科学分野:
- グローバルヘルス;感染症;微生物学
背景:
- 国際的な旅行は、世界的な薬剤耐性(AMR)の拡散の重要な推進要因である。;特に低中所得国(LMIC)で国外で入院した小児は、多剤耐性菌(MDRO)定着のリスクがある。;小児集団における旅行関連MDROに関する研究は限られている。
研究 の 目的:
- 国外で入院した後の小児におけるMDRO定着の有病率を評価すること。;小児患者における旅行関連MDRO定着に関連する危険因子を特定すること。
主な方法:
- HUSヘルシンキ大学病院(2010-2024年)からのMDROスクリーニングデータの分析。;適格基準:過去12か月以内に国外で入院した小児患者。;MDRO定着の独立した危険因子を特定するための多変量解析。
主要な成果:
- スクリーニングを受けた小児患者459人中158人(34.4%)がMDROに定着していた。;一般的なMDROには、ESBL-PE(29.0%)およびMRSA(7.6%)が含まれた。;CPEは3.1%で同定された。;定着の独立した危険因子は、抗生物質の使用、旅行の種類、および国の所得水準であり、低中所得国でより高い割合を示した。
結論:
- 国外で入院した小児ではMDRO定着が蔓延しており、国の所得水準との間に強い逆相関がある。;特にLMICからのケアのために国外から帰国した小児患者にとって、スクリーニングと感染管理は非常に重要である。;標的介入は、VFR旅行、外国での居住、および最近の抗生物質の使用をさらなる危険因子として考慮すべきである。
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