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Updated: Jan 23, 2026

Three-Dimensional Collagen Matrix Scaffold Implantation as a Liver Regeneration Strategy

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スピロ骨格：合成戦略と薬理活性

Aziz Moumad¹, Abderrazzak Bouhaoui¹, Mohammed Eddahmi¹

¹Chemicals Process and Applied Materials Team, Polydisciplinary Faculty, Sultan Moulay Slimane University, Beni Mellal, Morocco.

Future medicinal chemistry

|January 22, 2026

Abstract:

Many polycyclic compounds have been reported to possess a significant pharmacological activity, among them spirocyclic derivatives. Natural alkaloids containing spiro-carbons are widely distributed in nature and exhibit diverse pharmacological properties, such as antitumor, antimycobacterial, antitubercular, antimalarial, and antimicrobial activities, and others demonstrated by theoretical studies, such as molecular docking. In addition to their medical uses, some spirocompounds find applications in agriculture and industry practices. This review is an endeavor to highlight the current methods to synthesize spirocyclic compounds and their pharmacological interests reported since the end of the twentieth century.

キーワード:

スピロ複素環アルキル化環化付加反応薬理活性転位反応環拡大

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Non-invasive Strategies for Chronic Manipulation of DREADD-controlled Neuronal Activity

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