慢性完全閉塞虚血性心疾患に対する経皮的冠動脈形成術における心嚢穿刺に対するプロタミン
Sant Kumar1,2, Sudhir Thotakura1,3, Kathleen E Kearney1
1Division of Cardiology, Department of Medicine, University of Washington, Seattle, WA, USA.
Journal of cardiovascular pharmacology
|January 22, 2026
まとめ
慢性完全閉塞虚血性心疾患に対する経皮的冠動脈形成術（CTO PCI）穿刺に対するプロタミン投与は安全である。本研究では、プロタミンを投与された患者と投与されなかった患者の間で、入院中または1年後の転帰に有意な差は見られなかった。
背景:
- Unfractionated heparin reversal with protamine is common in percutaneous coronary intervention (PCI).; Data on protamine's safety and outcomes in chronic total occlusion PCI (CTO PCI)-related perforations are limited.; Assessing protamine's impact in this specific high-risk scenario is crucial for clinical practice.
結論:
- Protamine administration for CTO PCI-related perforation appears safe.; There is no evidence of additional clinical benefit from protamine use in this context.; Current practice of protamine use in CTO PCI perforations warrants re-evaluation based on these findings.
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