一般パラメトリック回帰モデルにおける治療効果の異質性評価方法の比較
Yao Chen1, Sophie Sun2, Konstantinos Sechidis3
1Advanced Methodology and Data Science, Novartis Pharmaceuticals Corporation, East Hanover, New Jersey, USA.
Statistics in medicine
|January 22, 2026
まとめ
本研究では、回帰モデルにおける治療効果の異質性を評価する方法を比較する。スコア残差に基づく方法は、治療効果修飾因子を特定するための実用的で信頼性の高いツールとして強調されている。
科学分野:
- 生物統計学; 統計モデリング; 臨床試験分析
背景:
- 治療効果の異質性の評価は、個別化医療にとって重要である。パラメトリック回帰モデルは一般的に使用されるが、異質性評価のための堅牢な方法が必要である。
主な方法:
- 標準的な尤度比検定、ブートストラップ尤度比検定、およびGoemanのグローバル検定の比較。変種を含む治療効果のスコア残差に基づく検定に焦点を当てる。シミュレーション研究とイベント発生までの時間に関する臨床試験での実証。
結論:
- スコア残差に基づく方法は、治療効果の異質性を評価するために推奨される。これらのアプローチは、臨床的意思決定に貴重な洞察を提供する。これらの方法の有用性は、実際の臨床設定で検証されている。
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