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多発性頭蓋放射線照射コースにおける深部脳刺激リードへの放射線被曝:症例提示
Adel Azghadi1,2, Kyle O'Carroll3,2, Haley K Perlow3,2
1Department of Neurological Surgery, University Hospitals Cleveland Medical Center, Cleveland.
Journal of neurosurgery. Case lessons
|January 22, 2026
まとめ
深部脳刺激(DBS)デバイスを有するパーキンソン病患者にとって、放射線療法は高線量であっても安全です。がん治療中にDBS機能を維持するためには、慎重な計画とモニタリングが重要です。
科学分野:
- 脳神経外科
- 放射線腫瘍学
- 神経学
背景:
- 深部脳刺激(DBS)はパーキンソン病(PD)の標準治療です。
- 脳腫瘍はますます一般的になっており、PDやDBSと共存することもあります。
- 活動中のDBSデバイスを有する患者に対する放射線療法の安全性に関するデータは限られています。
研究 の 目的:
- 活動中のDBSデバイスを有するPD患者における放射線療法の安全性と実現可能性を評価すること。
- 高累積放射線量がDBSデバイス機能に与える影響を評価すること。
主な方法:
- 脳転移および両側DBSリードを有する69歳男性PD患者の症例報告。
- 患者は定位放射線手術および海馬回避全脳放射線療法を受けました。
- DBSデバイス機能は治療期間中モニタリングされ、デバイスへの累積線量は47 Gyを超えました。
主要な成果:
- DBSデバイスは、インピーダンスの変化や症状の悪化なしに完全に機能し続けました。
- 類似症例のレビューにより、DBSコンポーネントは一般的に放射線量によく耐えることが示唆されています。
- 現在、DBS患者に対する放射線療法の標準的な安全プロトコルは確立されていません。
結論:
- 放射線治療は、綿密に計画およびモニタリングされれば、DBSデバイスを有する患者にとって実現可能かつ安全です。
- 高累積放射線量はDBS機能性を損なわない可能性があります。
- 中性子汚染と線量分布への注意が不可欠であり、学際的な協力が不可欠です。
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