コロンビアのサバナ・デ・ボゴタにある5500年前のトレポネマ・パリドムのゲノム
Davide Bozzi1,2, Nasreen Z Broomandkhoshbacht3, Miguel Delgado4,5,6
1Department of Computational Biology, University of Lausanne, Lausanne, Switzerland.
Science (New York, N.Y.)
|January 22, 2026
まとめ
コロンビアで発見された 5500年前のトレポネマのゲノムは 以前は知られていなかった 血統を示しています この古代の病原体は ヨーロッパ人との接触や 梅毒の多様化より 何千年も前に アメリカ大陸に存在していました
科学分野:
- パレオゲノミクス
- 進化的微生物学
- 古代のDNA分析
背景:
- トレポネマトーシスは,Treponema pallidum亜種 (梅毒,yaws,bejel, pinta) によって引き起こされ,ヒトでは長い歴史があります.
- トレポネマ病原体の進化史と古代の多様性は十分に理解されていない.
- これまでの研究では 細菌の進化の深い過去をたどるための 古代のゲノムデータがなかったのです
研究 の 目的:
- トレポネマ・パリドムの進化史を再構築する
- アメリカ大陸における トレポネマル病原体の 古代存在と多様性を調査する
- 古代のDNAを使って トレポネマル病原体の ゲノム記録を拡張する
主な方法:
- 5500年前のトレポネマ (TE1-3) の古代DNA (aDNA) 抽出と全ゲノム配列決定
- 古代のゲノムの進化的位置を現代のTreponema pallidum亜種と比較して分析する.
- ゲノムデータの生物情報分析により,集団の歴史と分岐時間を推測する.
主要な成果:
- 5500年前のトレポネマのゲノム (TE1-3) が,コロンビアの中 Holocene 狩猟採集者の遺骸から回収されました.
- 系統遺伝学的分析により,TE1-3はTreponema pallidumの全ての既知の亜種との姉妹系統として位置づけられた.
- この古代の血統は現代の亜種と ヨーロッパとの接触の多様化に先立ち アメリカ大陸の深い歴史を示しています
結論:
- TE1-3ゲノムの発見は,Treponema pallidumの既知の多様性を大幅に拡大しています.
- この発見は,ヨーロッパ人による植民地化の千年前のアメリカ大陸における トレポネマル病原体の古代存在の 分子証拠を提供します.
- この研究は,トレポネマ病原体の進化と地理的分布に関する新しい分子タイムラインを確立しています.
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