関連する実験動画

Updated: Jan 24, 2026

Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment

Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment

Published on: April 19, 2024

肝切除術における腹腔鏡手術は、開腹手術と比較して肝石症に対してより良い結果をもたらす：ランダム化比較試験および傾向スコアマッチング研究のメタアナリシス

Gang Tang¹, Jie Zhang, Ting Jiang

¹Division of Biliary Tract Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

International journal of surgery (London, England)

|January 22, 2026

要旨

Background:

Laparoscopic hepatectomy (LH) is used more commonly for hepatolithiasis, but high-level evidence is still scarce. This meta-analysis aimed to compare the short-term outcomes between LH and open hepatectomy (OH) for hepatolithiasis using data collected from randomized controlled trials (RCTs) and propensity score-matched (PSM) studies.

Materials And Methods:

We searched the EMBASE, Web of Science, Scopus, PubMed, and Cochrane Library databases for RCTs and PSM studies comparing LH and OH. Risk ratios (RRs) and mean differences (MDs) with 95% confidence intervals (CIs) were calculated.

Results:

Ten studies encompassing 2 RCTs and 8 PSM studies were included, with a total of 1898 patients (LH group: 936 patients; OH group: 962 patients). Compared with OH, LH was associated with a lower overall morbidity (RR, 0.59), major complications (RR, 0.57), wound infection (RR, 0.27), intestinal obstruction (RR, 0.43), stone recurrence (RR, 0.49) and blood transfusion rates (RR, 0.74), less blood loss (MD, -65.97 mL), shorter length of stay (MD, -3.22 days), time to first flatus (MD, -0.76 days), time to oral intake (MD, -1.21 days), and time to ambulation (MD, -0.90 days). No significant differences were observed between LH and OH in initial stone clearance (RR, 1.03), final stone clearance (RR, 1.00), mortality (RR, 1.63), or operative time (MD, 16.90 min).

Conclusions:

Although LH and OH had similar surgical outcomes, LH had the perioperative advantage over OH in decreasing overall morbidity, major complications, wound infection, intestinal obstruction, stone recurrence, blood transfusion rates, blood loss, length of stay, time to first flatus, time to oral intake, and time to ambulation. Further RCTs evaluating the potential advantages of LH over OH are warranted.

キーワード:

肝石症腹腔鏡下肝切除術メタアナリシス開腹肝切除術術後合併症

さらに関連する動画

Inverse Probability of Treatment Weighting Propensity Score using the Military Health System Data Repository and National Death Index

Inverse Probability of Treatment Weighting Propensity Score using the Military Health System Data Repository and National Death Index

Published on: January 8, 2020

Laparoscopic Anterior Right Hepatectomy: A Single-Center Experience

Laparoscopic Anterior Right Hepatectomy: A Single-Center Experience

Published on: December 4, 2023

関連する概念動画

Comparing the Survival Analysis of Two or More Groups

Comparing the Survival Analysis of Two or More Groups

Survival analysis is a cornerstone of medical research, used to evaluate the time until an event of interest occurs, such as death, disease recurrence, or recovery. Unlike standard statistical methods, survival analysis is particularly adept at handling censored data—instances where the event has not occurred for some participants by the end of the study or remains unobserved. To address these unique challenges, specialized techniques like the Kaplan-Meier estimator, log-rank test, and...

Bioequivalence Experimental Study Designs: Completely Randomized and Randomized Block Designs

Bioequivalence Experimental Study Designs: Completely Randomized and Randomized Block Designs

Body:Bioequivalence experimental study designs are crucial methodologies used in evaluating and comparing the bioavailability of different drug products. These designs are categorized into various types: completely randomized, randomized block, repeated measures, cross and carry-over, and Latin square designs.Completely randomized designs involve randomly allocating treatments to all subjects participating in the experiment. This allocation is achieved by assigning unique random numbers to...

Sign Test for Matched Pairs

Sign Test for Matched Pairs

The sign test for matched pairs offers a robust method for comparing two paired samples, often for the effects of an intervention in one of them. This method is very useful in situations where the underlying distribution of the data is unknown. The test compares two related samples—often pre- and post-treatment measurements on the same subjects—to determine if there are significant differences in their median values.
To conduct the sign test, we first calculate the differences in...

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...

Statistical Software for Data Analysis and Clinical Trials

Statistical Software for Data Analysis and Clinical Trials

Statistical software is pivotal in data analysis and clinical trials by providing tools to analyze data, draw conclusions, and make predictions. These software packages range from simple data management applications to complex analytical platforms, supporting various statistical tests, models, and simulation techniques. Their significance lies in their ability to handle vast amounts of data with precision and efficiency, enabling researchers to validate hypotheses, identify trends, and make...

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...