Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Molecular Models02:00

Molecular Models

43.6K
Physical models representing molecular architectures of chemical compounds play essential roles in understanding chemistry. The use of molecular models makes it easier to visualize the structures and shapes of atoms and molecules.
43.6K
Language01:16

Language

898
Language is a unique communication system that uses words and systematic rules to organize and transmit information. Unlike other forms of communication, which may involve postures, movements, odors, or vocalizations, language relies on symbols and grammar. This makes human communication distinct from that of other species, who also communicate but do not use language in the same way humans do.
Corballis and Suddendorf (2007) and Tomasello and Rakoczy (2003) highlight the role of language in...
898
Components of Language01:24

Components of Language

796
Language, whether spoken, signed, or written, consists of specific components: lexicon and grammar. The lexicon is the vocabulary of a language, comprising its words. Grammar is the set of rules used to convey meaning through the lexicon. For example, English grammar adds “-ed” to most verbs to indicate past tense. Words are formed by combining phonemes, which are the basic sound units of a language. Different languages have different sets of phonemes (e.g., “ah” vs.
796
Language Development01:22

Language Development

877
Children master language quickly and with relative ease, supported by both biological predisposition and reinforcement. B. F. Skinner (1957) proposed that language is learned through reinforcement, while Noam Chomsky (1965) argued that language acquisition mechanisms are biologically determined.
The critical period for language acquisition suggests that the ability to acquire language is at its peak early in life. As people age, this proficiency decreases. Language development begins very...
877
Language and Cognition01:27

Language and Cognition

741
Language serves as a bridge between ideas and communication, influencing how individuals perceive and interact with the world. Psychologists have long debated whether language shapes thought or vice versa. This discussion gained grip with Edward Sapir and Benjamin Lee Whorf in the 1940s, who proposed that language determines thought, a concept known as linguistic determinism. They suggested that the vocabulary and structure of a language influence how its speakers think and perceive reality.
741
Virtual Work01:20

Virtual Work

1.4K
The principle of virtual work states that if a body is in static and dynamic equilibrium, then the sum of all the virtual work done by all external forces and couple moments for any given virtual displacement must be zero.
In static equilibrium, a body can experience an imaginary or virtual movement, such as displacement or rotation. The virtual work done by a force is equal to the dot product of force and virtual displacement in the direction of the force. When it comes to virtually rotating a...
1.4K

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Novel Dual Soft Drug Strategy Enables Development of Topical Androgen Receptor Antagonists with Enhanced Efficacy and Optimized Safety for Androgenetic Alopecia.

Journal of medicinal chemistry·2026
Same author

Small Molecules in Development for the Treatment of Sepsis: Insights into Drug Targets and Molecular Mechanisms.

Journal of medicinal chemistry·2026
Same author

Discovery of an Indole-Based p53-Y220C Reactivator with <i>In Vivo</i> Antitumor Activity via Structure-Guided Design.

Journal of medicinal chemistry·2026
Same author

A‑type potassium channels mediate the inhibitory effect of β‑hydroxybutyrate on CA1 pyramidal neurons in an immature mouse model of kainic acid‑induced status epilepticus.

Epilepsy research·2026
Same author

Regional homogeneity and interhemispheric connectivity alterations in major depressive disorder.

Asian journal of psychiatry·2026
Same author

The effects of rTMS over orbitofrontal cortex on cognitive functions in first-episode schizophrenia.

Psychological medicine·2026
Same journal

DeepDPM: A Deep Learning Method for MoRFs Prediction Based on Wavelet Transform and Dynamic Convolutional Attention Mechanism.

Journal of chemical information and modeling·2026
Same journal

Graph-Based Generation and Reduction of Complex Chemical Reaction Networks.

Journal of chemical information and modeling·2026
Same journal

Modeling the Sensitivity of Large-Scale Virtual Screening to Scoring Function Accuracy, Artifacts, and Library Composition.

Journal of chemical information and modeling·2026
Same journal

Machine Learning-Driven Discovery of Indole/Oxoindole-Piperazine Scaffolds as Dual MAO-B/Sig-1R Ligands for Neurodegenerative Disorders.

Journal of chemical information and modeling·2026
Same journal

Mapping Evolution of Molecules across Biochemistry with Assembly Theory.

Journal of chemical information and modeling·2026
Same journal

Structural Proteomics-Based Deciphering of Hydrophobic Packing Fingerprints Informing Protein Thermostability in TIM Barrels.

Journal of chemical information and modeling·2026
関連記事をすべて見る

関連する実験動画

Updated: Jan 24, 2026

Direct Imaging of Laser-driven Ultrafast Molecular Rotation
10:52

Direct Imaging of Laser-driven Ultrafast Molecular Rotation

Published on: February 4, 2017

10.1K

CoDrug: テキスト駆動型分子仮想スクリーニングおよびマルチプロパティ最適化フレームワーク（マルチモーダル言語モデルを介して）

Rui Gu1, Yingxu Liu1, Bingxing Zhu1

  • 1School of Science, China Pharmaceutical University, Nanjing 210009, China.

Journal of chemical information and modeling
|January 22, 2026
PubMed
まとめ
この要約は機械生成です。

CoDrugは、テキストと分子構造を利用する新しい創薬AIフレームワークです。仮想スクリーニングと分子最適化を加速し、特に3Dデータが限られている場合に有効です。

背景:

  • 従来の分子スクリーニングは計算コストが高く、完全な3Dタンパク質構造に依存しています。
  • 信頼性の高い3D構造の欠如は、創薬を妨げます。
  • 既存の方法は、速度とアクセシビリティに限界があります。

結論:

  • CoDrugは、初期段階の創薬のためのスケーラブルで柔軟なパラダイムを提供します。
  • 自然言語インターフェースは、化学者の技術的障壁を低くします。
キーワード:
AI創薬仮想スクリーニング分子最適化マルチモーダル学習大規模言語モデル

さらに関連する動画

Light-driven Molecular Motors on Surfaces for Single Molecular Imaging
08:40

Light-driven Molecular Motors on Surfaces for Single Molecular Imaging

Published on: March 13, 2019

12.0K
A Multimodal Imaging Framework to Advance Phenotyping of Living Label-free Breast Cancer Cells
10:37

A Multimodal Imaging Framework to Advance Phenotyping of Living Label-free Breast Cancer Cells

Published on: August 22, 2025

1.2K

関連する実験動画

Last Updated: Jan 24, 2026

Direct Imaging of Laser-driven Ultrafast Molecular Rotation
10:52

Direct Imaging of Laser-driven Ultrafast Molecular Rotation

Published on: February 4, 2017

10.1K
Light-driven Molecular Motors on Surfaces for Single Molecular Imaging
08:40

Light-driven Molecular Motors on Surfaces for Single Molecular Imaging

Published on: March 13, 2019

12.0K
A Multimodal Imaging Framework to Advance Phenotyping of Living Label-free Breast Cancer Cells
10:37

A Multimodal Imaging Framework to Advance Phenotyping of Living Label-free Breast Cancer Cells

Published on: August 22, 2025

1.2K
  • 言語駆動型仮説と構造誘導型分子設計の統合を加速します。