関連する実験動画

Updated: Jan 24, 2026

High-throughput Analysis of Mammalian Olfactory Receptors: Measurement of Receptor Activation via Luciferase Activity
12:02

High-throughput Analysis of Mammalian Olfactory Receptors: Measurement of Receptor Activation via Luciferase Activity

Published on: June 2, 2014

13.0K

クラスIIの嗅覚受容体によって媒介される脂肪酸の匂いの検出に関するメカニズム的な洞察

Xiang Han1, Ming-Hui Zhang2, Nai-Kang Rong1

  • 1Shandong Provincial Third Hospital, Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan 250012, China; NHC Key Laboratory of Otorhinolaryngology, Qilu hospital and New Cornerstone Science Laboratory, Advanced Medical Research Institute, Cheeloo College of Medicine, Shandong University, Jinan 250012, China.

Cell
|January 22, 2026
PubMed
まとめ

研究者達は,クラスIIのオドラント受容体 (ORs) が 匂いの分子を認識する方法の構造的基礎を明らかにした. この研究は重要な相互作用と活性化メカニズムを明らかにし,嗅覚受容体を標的とする薬の開発の可能性を明らかにした.

キーワード:
オールFR110クリオ・エム薬物開発嗅覚受容体構造不飽和脂肪酸の代謝物質

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