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Updated: Jan 24, 2026

Three-dimensional Alginate-bead Culture of Human Pituitary Adenoma Cells

Three-dimensional Alginate-bead Culture of Human Pituitary Adenoma Cells

Published on: February 18, 2016

下垂体腺腫患者における閉塞性睡眠時無呼吸と下垂体機能の相関

Zitong Wang¹, Qi Li², Junjie Zhao¹

¹Department of Otorhinolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China; Shaanxi Provincial Key Laboratory for Precision Diagnosis and Treatment of Otorhinolaryngology, Xi'an, China.

Respiratory medicine

|January 22, 2026

要旨

Purpose:

The aim of this study was to analyze the correlation between pituitary function and obstructive sleep apnea (OSA) in pituitary adenomas (PA) patients, and to investigate the effect of related hormone levels on the severity of OSA.

Methods:

The clinical data of 82 patients with PA aged 18-70 years admitted to the Department of Neurosurgery, Xi'an Jiaotong University Affiliated Hospital from March 2023 to February 2025 were retrospectively collected and divided into functional and non-functional PA group.

Results:

Functional PA patients were younger and had a higher platelet-lymphocyte ratio (all p<0.05). Among the PSG related parameters, Patients with functional PA showed higher apnea-hypopnea index (AHI), total sleep time spent with arterial oxygen saturation<90% and longest apnea duration and oxygen desaturation index with >3% desaturation (all p<0.01). In terms of pituitary function parameters, free triiodothyronine (FT3) and insulin-like growth factor-1 (IGF-1) were significantly increased in OSA group, while the levels of cortisol, estradiol and progesterone were all lower (all p<0.05). Correlation analysis showed that AHI was positively correlated with FT3 and IGF-1. After adjusting for confounding factors, mediation analysis based on regression revealed that FT3 and IGF-1 mediated the association between PA and OSA severity.

Conclusion:

OSA was more severe in functional PA patients compared with non-functional PA patients. FT3 and IGF-1 are reliable predictors of AHI in PA patients, and may become important indicators for early clinical diagnosis of OSA in PA patients. Larger prospective studies are needed to further clarify the relationship between PA and OSA in the future.

キーワード:

閉塞性睡眠時無呼吸下垂体腺腫下垂体機能

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