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Updated: Jan 24, 2026

Synthesis and Calibration of Phosphorescent Nanoprobes for Oxygen Imaging in Biological Systems

Synthesis and Calibration of Phosphorescent Nanoprobes for Oxygen Imaging in Biological Systems

Published on: March 3, 2010

新規4-C-分岐ピロリジン含有イミノシュガーの合成と生物学的プロファイル

Monika Tvrdoňová¹, Yuliia Zuzak¹, Martina Bago Pilátová²

¹Institute of Chemical Sciences, Department of Organic Chemistry, P.J. Šafárik University, Moyzesova 11, 041 54 Košice, Slovak Republic.

Bioorganic & medicinal chemistry letters

|January 22, 2026

Abstract:

A novel 4-C-branched sugar mimetic based on a 1,4-dideoxy-1,4-imino-d-lyxitol (DIL) scaffold was designed and synthesised. Its construction features an early-stage introduction of the side chain via an OCM reaction followed by an alkylative cyclisation, providing the desired heterocyclic system. The subsequent interconversion of functional groups accompanied by the selective deprotection protocol allowed the tetrahydrofuran ring to be cleaved. Cell viability experiments revealed a cytotoxic effect of the target compound comparable to that of cisplatin on the A2058 and MCF-7 cancer cell lines. Moreover, 4-C-tridecyl-DIL proved to be moderately active against Jurkat and HeLa cells (IC₅₀ = 20.58 μM and 22.7 μM, respectively). In addition, docking studies identified the binding modes of this novel pyrrolidine-based iminosugar to human β-glucocerebrosidase.

キーワード:

細胞毒性イミノシュガーメタセシスピロリジン β-グルコセレブロシダーゼ

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Multilevel Microdissection and Functional-Structural Profiling of Human Renal Arterial Branches

Multilevel Microdissection and Functional-Structural Profiling of Human Renal Arterial Branches

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Biological Compatibility Profile on Biomaterials for Bone Regeneration

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