関連する実験動画

Updated: Jan 24, 2026

Comprehensive Analysis of Drug Response using the FLICK Assay

Comprehensive Analysis of Drug Response using the FLICK Assay

Published on: June 6, 2025

薬剤性過敏症症候群：薬物警戒活動の記述的分析

Eleonora Castellana¹, Maria Rachele Chiappetta²

¹Hospital Pharmacy, Azienda Ospedaliero Universitaria Città della Salute e della Scienza di Torino, Turin, Italy ecastellana@cittadellasalute.to.it.

European journal of hospital pharmacy : science and practice

|January 22, 2026

要旨

Objectives:

Drug rash with eosinophilia and systemic symptoms (DRESS) is a rare but potentially fatal adverse drug reaction characterised by cutaneous and systemic involvement. This study aimed to analyse patients with DRESS reported through the US Food and Drug Administration Adverse Event Reporting System (FAERS).

Methods:

All DRESS reports submitted to FAERS between 1 January 2003 and 13 October 2025 were extracted. Patient characteristics were analysed descriptively according to severity, sex, age group and suspected drugs.

Results:

A total of 26 831 patients with DRESS were identified, of which 99.67% were classified as having a serious adverse reaction. Overall mortality was 6.9% (1846 deaths). Female patients were more frequently affected than male patients. Adults aged 18-64 years represented the largest group. Allopurinol, lamotrigine and vancomycin were the most frequently suspected drugs, accounting for over 30% of reports.

Conclusions:

DRESS remains a severe adverse drug reaction. Early recognition and continuous pharmacovigilance are essential to reduce associated morbidity and mortality.

キーワード:

皮膚科薬物関連の副作用および有害反応エビデンスに基づく医療教育部門病院教育薬局継続エビデンスに基づく医療薬物警戒活動診療ガイドライン

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Systemic and Local Drug Delivery for Treating Diseases of the Central Nervous System in Rodent Models

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