眼または全身感染症後の乾性角結膜炎:システマティックレビュー
Sowmya V Kothandan1, Sayan Basu, Swati Singh
1Brien Holden Eye Research Center (BHERC) (S.V.K., S.B, S.S.), LV Prasad Eye Institute, Hyderabad, Telangana, India; Shantilal Shanghvi Cornea Institute (S.V.K., S.B, S.S.), LV Prasad Eye Institute, Hyderabad, Telangana, India; and Prof. Krothapalli Ravindranath Ophthalmic Research Biorepository (S.V.K., S.B, S.S.), LV Prasad Eye Institute, Hyderabad, Telangana, India.
Eye & contact lens
|January 23, 2026
まとめ
HIV、C型肝炎、COVID-19などの感染症は乾性角結膜炎(DED)を引き起こす可能性があります。多くの場合軽度ですが、感染症の理解
科学分野:
- 眼科学および感染症学。眼表面疾患と全身/局所感染症の交差領域を調査します。
背景:
- 乾性角結膜炎(DED)は、様々な感染症に続発する状態である可能性があります。感染関連DEDの特性と転帰を理解することは、患者管理にとって重要です。
研究 の 目的:
- 眼または全身感染症に続発する乾性角結膜炎(DED)の特性を明らかにすること。感染誘発性DEDの重症度、原因物質、治療転帰を分析すること。
主な方法:
- PubMed、Scopus、Cochraneデータベースのシステマティック文献レビュー。感染後(例:HIV、C型肝炎、COVID-19、ヘルペス角膜炎)のDED発症に焦点を当てた28件の研究の分析。DED症状の重症度、徴候、感染症の種類、管理転帰の評価。
主要な成果:
- 一般的に原因として関与する感染症には、HIV、C型肝炎、COVID-19、ヘルペス角膜炎などがあります。DEDの症状は通常軽度であり、涙液層パラメータはDEWS II基準を満たさないことが多くありました。一部の重症感染症(進行した肝炎や特定のウイルス感染症(EBV、HIV))では、涙液層の異常が認められました。
結論:
- 細菌およびウイルス感染症は、後遺症として乾性角結膜炎(DED)を引き起こす可能性があります。感染症に関連するDEDは、症状的には一般に軽度であり、涙液層への影響は様々です。報告の一貫性の欠如は、DEDの原因における感染症の役割の完全な理解を妨げています。
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