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Updated: Jan 24, 2026

An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause

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性機能、性活動、性的な苦痛：手術的閉経後の24か月（閉経後の状況（WHAM）-前向き対照研究）

Martha Hickey¹, Trevor Tejada-Berges², Susan M Domchek³

¹Department of Obstetrics, Gynaecology and Newborn Health, University of Melbourne and the Royal Women's Hospital, Melbourne, Victoria, Australia.

BJOG : an international journal of obstetrics and gynaecology

|January 23, 2026

要旨

Objective:

To determine the effect of surgical menopause (risk-reducing salpingo-oophorectomy, RRSO) on sexual function and the modifying effects of HRT.

Design:

Prospective observational study of women undergoing RRSO and age-matched comparison group who retained their ovaries.

Setting:

High-risk clinics and general population.

Methods:

Sexual function was measured at baseline, 3, 6, 12 and 24 months.

Main Outcome Measures:

Primary outcome was sexual function at 24 months using the Female Sexual Function Index (FSFI). Secondary outcomes included the Fallowfield Sexual Activity Questionnaire (SAQ) and Female Sexual Distress Scale-Revised (FSDS-R).

Results:

Baseline sexual function was similar between groups. At 24 months, sexual dysfunction increased from 19% to 42% after RRSO versus 24% to 29% in comparisons (Odds Ratio (OR) 1.9, 95% CI 0.7-5.1; p = 0.21). Compared to comparisons, sexual desire (-0.4, p = 0.02), arousal (-0.7, p < 0.001), lubrication (-0.6, p = 0.01) and satisfaction (-0.6, p < 0.001) were significantly reduced in the RRSO group. Sexual pain (-0.5, p = 0.05) and discomfort (-1.0, p < 0.001) increased after RRSO; sexual habit was unchanged. Sexual distress nearly quadrupled in the RRSO group (OR 3.7, 95% CI 1.6-9.0; p = 0.003). After RRSO, 61% commenced HRT. HRT was not associated with sexual function, activity or distress.

Conclusions:

Sexual dysfunction and distress increased after RRSO. Use of HRT was not associated with better sexual function.

キーワード:

HRT RRSO リスク低減サルピングoo-卵巣摘出術性機能手術的閉経

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