犬における先天性神経鞘腫

Jesse Cole¹, Paula A Schaffer^1,2, Natalie M Kirk^1,2

¹Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO, USA.

Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc

|January 23, 2026

まとめ

若齢のレオンベルガー犬において、まれな先天性神経鞘腫と診断された。この腫瘍は、特有の偽玉ねぎ様形成と多発性の色素細胞分化を示し、犬のがんに関する知見を提供する。

科学分野:

獣医病理学;犬のがん;腫瘍性疾患

背景:

犬における先天性腫瘤はまれである。;神経鞘腫は犬集団ではまれにしか記載されていない。;早期発症の胸部腫瘤は、徹底的な組織病理学的評価を必要とする。

研究の目的:

犬における先天性神経鞘腫の組織病理学的および免疫組織化学的特徴を明らかにすること。;まれな犬の腫瘍性疾患の症例を記録すること。;獣医学におけるまれな腫瘍タイプの理解に貢献すること。

主な方法:

胸部腫瘤生検の組織病理学的検査。;グリア酸性線維状タンパク質、PGP9.5、S100、Sox10、ラミニン、NeuN、melan A、PNL2に対する免疫組織化学的染色。;偽玉ねぎ様形成を含む腫瘍細胞の形態および配置の評価。

主要な成果:

腫瘤は、浸潤性で被包化されていない紡錘形細胞集団を特徴とした。;腫瘍組織内に偽玉ねぎ様形成が観察された。;免疫組織化学的検査により、グリア酸性線維状タンパク質およびPGP9.5に対して強い標識、S100およびSox10に対して中程度の標識、NeuN、melan A、PNL2に対して多発性の標識が明らかになった。;支持マトリックスは、強いラミニン免疫標識を示した。

結論:

組織病理学的および免疫組織化学的所見は、先天性神経鞘腫の診断を支持する。;本症例は、犬におけるこの腫瘍タイプのまれな発生例である。;本所見は、まれな犬の腫瘍性疾患に対する包括的な診断技術の重要性を強調する。

キーワード:

先天性犬神経鞘腫

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