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Updated: Jan 24, 2026

Author Spotlight: Advancing Research on Candida albicans Biofilm-Associated Prosthetic Joint Infections

Author Spotlight: Advancing Research on Candida albicans Biofilm-Associated Prosthetic Joint Infections

Published on: February 2, 2024

ペリプロステティック関節感染症に対するリファンピシン併用フルオロキノロン系薬剤とテトラサイクリン系薬剤の比較研究

Benoit Gachet^1,2, Olivier Robineau^1,2,3, Maxime Degrendel¹

¹Infectious Diseases Department, Gustave Dron Hospital, 155 rue du président CotyTourcoing, France.

Journal of bone and joint infection

|January 23, 2026

Abstract:

Objectives: Periprosthetic joint infections (PJIs) are predominantly caused by gram-positive bacteria. Fluoroquinolones (FQs), combined with rifampicin (RMP), are often used but may be unsuitable due to resistance, side effects, or intolerance. Second-generation tetracyclines (TTCs), such as doxycycline and minocycline, show promise as alternatives. This study compared the efficacy and tolerance of RMP-FQ versus RMP-TTC combinations in PJI treatment. Methods: A retrospective study at Tourcoing Hospital, France, reviewed staphylococcal- and streptococcal-related PJI cases treated with RMP-FQ or RMP-TTC from 2013 to 2021. Patients were followed up for 2 years. A Cox regression analysis was used to compare risk of failure. A propensity score using inverse probability of treatment weighting (IPTW) was performed to balance covariates. Results: Of 105 patients, 70 received RMP-FQ and 35 RMP-TTC. Infections were mainly monomicrobial (80 %). IPTW-adjusted Cox regression revealed no significant difference in treatment failure between the RMP-FQ and RMP-TTC groups (aHR 0.68; 95 % CI $=$ 0.32-1.4). Subgroup analyses suggested no difference for infections caused by S. aureus (HR 1.1; CI 95 % $=$ 0.3-4.0) or coagulase-negative staphylococci (CoNS) (HR 0.54; 95 % CI $=$ 0.1-2.1). Adverse events were similar in both groups (20 % vs. 19 %, $p > 0.9$ ). Conclusions: RMP-TTC therapy could be considered a potential therapeutic option for PJIs when FQs cannot be used.

キーワード:

ペリプロステティック関節感染症リファンピシンテトラサイクリンフルオロキノロン治療失敗副作用

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Combined In vivo Optical and µCT Imaging to Monitor Infection, Inflammation, and Bone Anatomy in an Orthopaedic Implant Infection in Mice

Combined In vivo Optical and µCT Imaging to Monitor Infection, Inflammation, and Bone Anatomy in an Orthopaedic Implant Infection in Mice

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