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Updated: Jan 24, 2026

A Gut-on-a-Chip Model to Study the Gut Microbiome-Nervous System Axis
Published on: July 28, 2023
脳卒中後不眠症に対する鍼治療:腸内細菌叢と脳腸相関を介したメカニズムに関する臨床研究のエビデンスマッピング
Dongwei Liu1, Jianying Zhang2, Yanlei Cui2
1Department of Emergency, Qingdao West Coast New Area People's Hospital, Qingdao, China.
Abstract:
The intestinal flora is an important physiological component of the gastrointestinal system and one of the sources of neurotransmitters. About 90% of neurotransmitters in the brain are produced in the human intestine. Poststroke insomnia is caused by damage to the internal and external structures of the brain, characterized by difficulties in falling asleep, shallow sleep, easy awakenings, and challenges in returning to sleep, all impacting patients' quality of life. Hypnotics have many adverse reactions in the treatment of insomnia, which can lead to drug resistance and relapse. The systematic review and meta-analysis of 41 randomized controlled trials (RCTs) with 3233 patients showed that all the results of RCTs were effective in acupuncture treating poststroke insomnia. Acupuncture regulates the imbalance of intestinal flora and controls the secretion of gut-brain peptides.
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