中心性網膜動脈閉塞症に対する24時間以降の高気圧酸素療法の検討:症例報告
Dóra Werling1, Tibor Rák2, Gábor Kanász3
1Department of Ophthalmology, University of Pécs Medical School Clinical Centre, Rákóczi u 2, Pécs 7623, Hungary.
Therapeutic advances in ophthalmology
|January 23, 2026
まとめ
中心性網膜動脈閉塞症(CRAO)は稀な緊急疾患です。高気圧酸素療法(HBOT)は、発症から48時間以内に開始された場合でも、CRAO患者の視力回復に有望な効果を示します。
科学分野:
- 眼科学
- 救急医学
- 高気圧医学
背景:
- 中心性網膜動脈閉塞症(CRAO)は、しばしば60歳以上の人に影響を与える、重篤な眼科的緊急事態です。
- 危険因子には、網膜虚血に寄与する高血圧、糖尿病、喫煙が含まれます。
- 高気圧酸素療法(HBOT)は、網膜の酸素供給を助けるCRAOのレベルIIb推奨事項です。
研究 の 目的:
- 中心性網膜動脈閉塞症(CRAO)患者における高気圧酸素療法(HBOT)の有効性を評価すること。
- HBOTが通常の血栓溶解ウィンドウ外で投与された場合のCRAOにおける視力回復を評価すること。
主な方法:
- CRAOと高血圧の70歳男性が、発症から48時間以内にHBOTを受けました。
- 診断ツールには、視力検査、生体顕微鏡検査、および光干渉断層計(OCT)が含まれていました。
主要な成果:
- 患者は突然の無痛性視力低下と、チェリーレッドスポットを含むCRAOの典型的な兆候を呈しました。
- HBOT後、患者は周辺視力の改善と光覚過敏の改善を経験しました。
- OCTは網膜浮腫と網膜下液を確認し、治療後部分的に改善しました。
結論:
- 発症から48時間後であっても、早期のHBOT介入により、CRAO症例において有意な視力改善が得られる可能性があります。
- チェリーレッドスポットの存在は、より良好な視力回復転帰と相関する可能性があります。
- CRAOに対するFDA承認薬ではありませんが、HBOTは、特に迅速に開始された場合に、潜在的に価値のある治療選択肢となります。
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