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Updated: Jan 24, 2026

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

多発性硬化症における軟膜増強は後部への偏りを示し、隣接する皮質におけるT1変化を示す

Ashley A Thommana¹, Erin S Beck^1,2, Matthew A Greenwald¹

¹Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA.

Multiple sclerosis journal - experimental, translational and clinical

|January 23, 2026

要旨

Background:

Leptomeningeal enhancement (LME) is a putative magnetic resonance imaging (MRI) marker of meningeal inflammation in multiple sclerosis (MS). 3D inversion-prepared fast-spin-echo sequence with real-reconstruction inversion recovery (Real-IR) MRI at 3 tesla (T) is highly sensitive to LME.

Objectives:

To assess LME prevalence across brain regions and characterize the relationship between LME and subtle cortical pathology.

Methods:

LME distribution patterns across brain regions were recorded for 90 adults (Age: 51 ± 11; women: 57; MS: 78) using 3T Real-IR. A subset of 15 participants had corresponding T₁-maps at 7T. T₁ relaxation times were calculated in the normal-appearing cortex subjacent to the LME, in comparison to the adjacent and homologue cortex.

Results:

243 LME foci were found across 65 participants (73%). One hundred and sixty-one (66.3%) LME foci were posterior to the central sulcus. Three of 15 7T participants had a cortical lesion nearby LME (3/49 foci). Mean T₁ times within cortex beneath LME (1734 ± 135 ms) were elevated compared to homologue (1668 ± 167 ms, p = .0052) and adjacent cortex (1651 ± 133 ms, p < .0001).

Conclusions:

Regional variations in LME distribution may point to topographical differences in the blood-meningeal barrier. Alterations in T₁ relaxation time observed in the cortex adjacent to LME may signify subtle tissue changes in the absence of cortical lesions.

キーワード:

MRI 多発性硬化症血液脳脊髄液バリア軟膜増強リアルインバージョンリカバリーMRI

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The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool

The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool

Published on: June 30, 2014

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

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