認知機能改善における栄養植物化学物質の有効性
Alexander Marsh1, Darren Quelch2, Marion Mackonochie3
1School of Psychological Science, Department of Clinical Neuropsychology, University of Bristol; Doctor of Clinical Psychology Programme, Cardiff University; University Hospital Bristol NHS Foundation Trust, Upper Maudlin Street, Bristol, BS2 8BJ.
The international journal of neuropsychopharmacology
|January 23, 2026
まとめ
バコパ・モンニエリやカメリア・シネンシスなどの植物化学物質は、健康な成人において認知機能への効果を示さなかった。オシマム・テヌイフロルムは実行機能の反応時間を改善する可能性があるが、さらなる研究が必要である。
科学分野:
- 神経科学
- 薬理学
- 統合医療
背景:
- 認知障害は増加しており、限定的な医薬品治療しかない。
- 植物化学物質は前臨床認知研究で有望視されている。
- 健康な認知または神経学的損傷の続発症における植物化学物質のエビデンスは収集されていない。
研究 の 目的:
- 植物化学物質が健康な個人の認知機能に与える影響を系統的にレビューすること。
- 特定の薬用植物の認知パフォーマンスに対する有効性を評価すること。
主な方法:
- Web of Science、PubMed、PsycNET、AYUSH Research Portalの系統的文献検索。
- 二重盲検および単盲検無作為化比較試験の包含。
- Curcuma longa、Bacopa monnieri、Ocimum tenuiflorum、Camellia sinensis、Centella asiatica、Ganoderma lingzhi、Rosmarinus officinalisに焦点を当てる。
主要な成果:
- バコパ・モンニエリ、オシマム・テヌイフロルム、またはカメリア・シネンシスを調査した7件の研究が包含基準を満たした。
- バコパ・モンニエリまたはカメリア・シネンシスは、処理速度、注意、記憶、言語、または精神運動機能において認知機能への効果を示さなかった。
- オシマム・テヌイフロルムは、実行機能タスクにおける反応時間の改善を示した。
結論:
- 現在のエビデンスは、健康な個人における認知増強のためのバコパ・モンニエリまたはカメリア・シネンシスの日常的な使用を支持していない。
- オシマム・テヌイフロルムは実行機能の改善の可能性を示しており、さらなる調査に値する。
- 認知機能に対する植物化学物質の有効性を確認するために、より厳密で長期間の試験が推奨される。
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