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Updated: Jan 24, 2026

Generation of Human Chimeric Antigen Receptor Regulatory T Cells

Generation of Human Chimeric Antigen Receptor Regulatory T Cells

Published on: January 3, 2025

急性骨髄性白血病におけるキメラ抗原受容体療法の実施における課題と解決策

Shivahamy Maheswaran¹, Caroline D Gordon¹, Evan C Chen²

¹Department of Medicine - Division of Hematology/Oncology, UMass Memorial Medical Center, UMass Chan Medical School, Worcester, Massachusetts, USA.

European journal of haematology

|January 23, 2026

Abstract:

The field of acute myeloid leukemia (AML) therapeutics has seen significant progress with respect to the development of targeted agents for specific mutational subsets. However, outcomes for patients with high-risk AML remain dismal, and curative intent therapy is often challenging to administer in this population. AML is a highly plastic entity that employs a variety of mechanisms to circumvent immunosurveillance. In the recent decade, preclinical evidence for chimeric antigen receptor-T (CAR-T) and chimeric antigen receptor-natural killer (CAR-NK) therapies has gained traction in a variety of other hematologic malignancies, but the translation of these therapies to patients with AML has been limited. In this review, we discuss contemporary challenges to the clinical translation of cell-based therapeutics in AML. We underscore practical solutions to facilitating the clinical availability of novel cell-based therapies in AML. These solutions include widening the narrow therapeutic window through better myeloid-specific CAR target validation, developing multi-antigen or tandem CAR products, optimizing the immune repertoire and bone marrow niche in AML, and enhancing scalability of cell-based therapeutics such that patients in local communities can benefit from ongoing efforts. These strategies may help improve the translational success of CAR-T and CAR-NK therapies in AML in the coming years.

キーワード:

CAR-NK CAR-T 急性骨髄性白血病白血病幹細胞標的療法

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