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Updated: Jan 25, 2026

Inoculation Strategies to Infect Plant Roots with Soil-Borne Microorganisms

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Published on: March 1, 2022

微生物におけるインジゴイジン生合成：戦略と応用

Xiaomin Zhao^1,2, Xue Leng^2,3, Yunzi Luo^1,2,4,3

¹Frontiers Science Center for Synthetic Biology (Ministry of Education), School of Synthetic Biology and Biomanufacturing, Tianjin University, Tianjin 300072, China.

ACS synthetic biology

|January 23, 2026

Abstract:

Indigoidine, a microbial-derived pyridone pigment, has emerged as a promising sustainable alternative to synthetic blue dyes in textile industry. Its biosynthesis is mediated by nonribosomal peptide synthetases (NRPSs), offering a favorable alternative to conventional chemical synthesis for pigment production. Recent advances in synthetic biology have facilitated the scalable engineering of microbial chassis strains, enabling industrial level pigment production. However, challenges persist in pathway optimization, titer improvement, and application diversity. In this review, we systematically examine microbial host systems, metabolic and enzyme engineering approaches, and synthetic biology techniques to enhance indigoidine production. This review offers a roadmap for advancing next-generation microbial cell factories for pigment manufacturing.

キーワード:

NRPS 生合成経路インジゴイジン代謝工学天然顔料合成生物学

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