関連する実験動画

Updated: Jan 25, 2026

Home-Based Prescribed Pulmonary Exercise in Patients with Stable Chronic Obstructive Pulmonary Disease

Home-Based Prescribed Pulmonary Exercise in Patients with Stable Chronic Obstructive Pulmonary Disease

Published on: August 24, 2019

安定慢性閉塞性肺疾患患者における大気質警報ベース介入の効果評価：前向き無作為化比較試験

Xiaohua Zhang¹, Shasha Xie¹, Xueshuai Cao¹

¹Department of General Medicine, Shanghai Fifth People's Hospital, Fudan University, Shanghai, China; Center for Community-Based Health Research, Fudan University, Shanghai, China.

Respiratory medicine

|January 23, 2026

要旨

Background:

Air pollution is a key modifiable trigger of acute exacerbations of chronic obstructive pulmonary disease (AECOPD), but the efficacy of real-time air quality alert interventions for community-dwelling stable COPD patients remains unvalidated.

Methods:

This prospective stratified randomized controlled trial (RCT) enrolled 255 stable COPD patients from 3 Shanghai community health centers, randomly assigned (1:1:1) to Control (routine management), Education (routine + pollution education), or Alert (routine + WeChat-based real-time AQI alerts) Groups. The primary outcome was 12-month AECOPD frequency. Secondary outcomes included pulmonary function, symptom scores (SGRQ/CAT/mMRC), and biomarkers. Analyses used negative binomial regression, nonparametric tests, and Generalized Estimating Equations (GEE) model.

Results:

226 patients (88.6% follow-up rate) completed the study. Compared to Control Group, Alert Group had 39.3% lower AECOPD risk (IRR=0.607, 95% CI:0.401-0.924); Education Group showed no significant reduction (IRR = 0.819, 95% CI: 0.543-1.236). Both intervention groups significantly improved SGRQ scores (Education: B = -7.192, 95% CI: -11.664, -2.720; Alert: B = -6.059, 95% CI: -10.518, -1.599). After GEE adjustment, only Alert Group had lower IL-8 (B=-0.950, 95% CI: -1.795, -0.104); pulmonary function was mostly unchanged, with no CD4⁺/CD8⁺ T-cell differences.

Conclusions:

WeChat-based air quality alerts reduced AECOPD risk and improved symptoms in stable COPD, outperforming pollution education, supporting digital environmental management in community COPD care.

キーワード:

急性増悪大気汚染大気質警報慢性閉塞性肺疾患地域ベースケアデジタルヘルス

さらに関連する動画

Author Spotlight: Efficacy of Auricular Pressure Bean Therapy in Reducing Wheezing Symptoms

Author Spotlight: Efficacy of Auricular Pressure Bean Therapy in Reducing Wheezing Symptoms

Published on: May 10, 2024

Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure

Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure

Published on: August 25, 2017

関連する概念動画

Chronic Obstructive Pulmonary Disease

Chronic Obstructive Pulmonary Disease

COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...

Chronic Obstructive Pulmonary Disease-I: Introduction

Chronic Obstructive Pulmonary Disease-I: Introduction

Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.

Chronic Obstructive Pulmonary Disease-V: Management

Chronic Obstructive Pulmonary Disease-V: Management

Managing Chronic Obstructive Pulmonary Disease (COPD) involves a multifaceted approach to reduce symptoms, prevent exacerbations, improve overall health status, and slow disease progression. Key strategies include lifestyle modifications, pharmacotherapy, supportive therapies, and, in some cases, surgery. Here is an overview of the primary COPD management strategies:
Smoking Cessation

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation

Chronic Obstructive Pulmonary Disease-V: Nursing Management

Chronic Obstructive Pulmonary Disease-V: Nursing Management

Nursing management of Chronic Obstructive Pulmonary Disease (COPD) is crucial for providing thorough care and support to patients. Nurses play an integral role in this process through detailed assessment, careful planning, targeted interventions, and ongoing evaluation. Here's an overview of the critical steps in nursing management for COPD.
Assessment

Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.

Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.

Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD: