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関連する概念動画

Classification of Illness01:17

Classification of Illness

8.6K
The meaning of illness is individualized to each person who experiences an alteration in health. In contrast, disease is a medical term indicating a pathological change in the structure and function of the body or mind. It is a condition that has specific symptoms and boundaries.
An illness is a response to a disease in which the person's level of functioning is changed compared with a previous level. The general classification of illness includes acute and chronic.
Acute illness is severe...
8.6K
Abnormal Proliferation02:23

Abnormal Proliferation

5.1K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.1K
Factors Affecting Illness01:18

Factors Affecting Illness

5.2K
When a person's physical, emotional, intellectual, social development or spiritual functioning is compromised, this deviation from a healthy normal state is called illness. Illness creates stress that in turn harms individuals. Irritation, anger, denial, hopelessness, and fear are behavioral and emotional changes an individual experiences in the phases of illness. A variety of factors influence a person's health and well-being.
For instance, risk factors are connected to illness,...
5.2K
Concepts of Health and Illness01:29

Concepts of Health and Illness

17.6K
Health is a condition of the body, mind, and spirit where an individual remains free from illness. Similarly, wellness is an active state, including living a lifestyle that promotes physical, mental, and emotional health. Physical health is critical for the overall well-being and can be affected by lifestyle, activity level, diet, and behavior. The highest attainable standard of health is a fundamental and universal human right. Consider Lisa, a fifteen-year-old born with congenital...
17.6K
Dimensions of Health and Illness01:21

Dimensions of Health and Illness

10.8K
The factors influencing the health-illness continuum can be internal or external and may or may not be under conscious control. They are related to the following eight human dimensions, and each dimension is interrelated to one other.
10.8K
Critical Region, Critical Values and Significance Level01:16

Critical Region, Critical Values and Significance Level

13.3K
The critical region, critical value, and significance level are interdependent concepts crucial in hypothesis testing.
In hypothesis testing, a sample statistic is converted to a test statistic using z, t, or chi-square distribution. A critical region is an area under the curve in  probability distributions demarcated by the critical value. When the test statistic falls in this region, it suggests that the null hypothesis must be rejected. As this region contains all those values of the...
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関連する実験動画

Updated: Jan 26, 2026

Use of a Central Venous Line for Fluids, Drugs and Nutrient Administration in a Mouse Model of Critical Illness
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重症患者における肝機能障害の異常

Philippe Meersseman1, Alexander Wilmer1, Lies Langouche2

  • 1Medical Intensive Care Unit, Department of General Internal Medicine, University Hospital Leuven.

Current opinion in critical care
|January 25, 2026
PubMed
まとめ

集中治療室（ICU）患者の最大40％が肝不全の影響を受け、死亡率が増加する。動的肝機能検査による早期発見と急性・慢性肝不全（ACLF）の理解が、より良い転帰のために不可欠である。

キーワード:
ICU急性肝不全急性・慢性肝不全肝不全敗血症

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Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
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Functional Human Liver Preservation and Recovery by Means of Subnormothermic Machine Perfusion
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関連する実験動画

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科学分野:

  • 集中治療医学
  • 肝臓病学
  • 内科学

背景:

  • 肝不全は重症患者（20～40％）によく見られ、予後不良と関連している。
  • 肝機能検査（LFT）の異常は、敗血症、薬物毒性、低酸素症、または既存の肝疾患に起因する可能性がある。
  • 肝不全は、ICU入室の主な理由であるか、入院中に発生する可能性がある。

研究 の 目的:

  • 重症患者における肝不全の理解における最近の進歩をレビューすること。
  • 急性・慢性肝不全（ACLF）の診断と管理を強調すること。
  • 早期検出と予後予測における動的肝機能検査の重要性を強調すること。

主な方法:

  • 重症病における肝不全に関する最近の文献のレビュー。
  • 動的肝機能検査（例：インドシアニングリーンクリアランス）に焦点を当てる。
  • 急性・慢性肝不全（ACLF）における進化する概念の探求。

主要な成果:

  • 動的肝機能検査は、早期検出と予後予測に役立つ。
  • 急性・慢性肝不全（ACLF）は、適時の介入を必要とする全身性疾患として認識されている。
  • 肝不全と多臓器不全の関連性を理解することが鍵となる。

結論:

  • 最近の進歩により、肝不全のメカニズム、診断、および管理の理解が向上した。
  • 特に急性・慢性肝不全（ACLF）に重点が置かれている。
  • 管理戦略の改善は、この患者集団にとって不可欠である。