帯状疱疹による上肢叢病変:PRISMAガイドラインに準拠した系統的症例レビュー
Francisco Jover-Diaz1, Lucia Parra-Muñoz2, Mar Trigueros-Rocamora2
1Miguel Hernández University, Infectious Diseases Unit, Spain; San Juan University Clinical Hospital, Alicante, Spain.
Journal of the neurological sciences
|January 25, 2026
まとめ
帯状疱疹(HZ)は、主に高齢者に稀な上肢叢病変を引き起こす可能性がある。早期診断と多面的治療は予後を改善するが、一部の患者は永続的な影響を経験する。
科学分野:
- 神経学; 感染症; 臨床医学
背景:
- 帯状疱疹(HZ)関連叢病変は、稀な神経学的合併症である。; 主に高齢者に影響を与えるが、既存の文献は散在する症例報告に限られている。; その発生率、病態生理、管理、および予後に関する重大な知識のギャップが残っている。
研究 の 目的:
- 帯状疱疹(HZ)による上肢叢病変の公表された臨床症例を系統的に分析すること。; HZ関連叢病変の疫学、臨床的特徴、診断方法、治療、および転帰を明らかにすること。; 厳格な方法論を用いて個々の患者データを統合することにより、知識のギャップに対処すること。
主な方法:
- PRISMA-IPDガイドラインを遵守した系統的レビューを実施した。; PubMed、Scopus、およびEMBASE(2000-2025)でHZ関連上肢叢病変の症例報告/シリーズを検索した。; 抽出されたデータには、人口統計、臨床、電気生理学的、および画像所見、治療、および転帰が含まれていた。
主要な成果:
- 60の記事から123人の患者が分析された(平均年齢69.5歳)。; ほとんどの症例は混合性運動/感覚障害(C5-C6皮膚分節)に関与し、糖尿病および免疫不全が一般的な併存疾患であった。; 完全回復は47%の症例で観察された。; 27%は永続的な後遺症があった。; 診断の遅延、免疫不全、軸索電図パターン、および70歳以上は、より悪い転帰と関連していた。
結論:
- このレビューは、HZ関連腕神経叢病変の包括的な統合を提供する。; 早期の臨床的および電気生理学的診断と多面的治療の重要性を強調する。; 患者管理と予後を改善するための標準化された診断プロトコルと前向き研究の必要性を強調する。
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