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Updated: Jan 27, 2026

Home-Based Prescribed Pulmonary Exercise in Patients with Stable Chronic Obstructive Pulmonary Disease

Home-Based Prescribed Pulmonary Exercise in Patients with Stable Chronic Obstructive Pulmonary Disease

Published on: August 24, 2019

慢性閉塞性肺疾患患者における日本人患者の手の握力：前向きコホート研究

Seiichi Kobayashi¹, Manabu Ono¹, Masatsugu Ishida¹

¹Department of Respiratory Medicine, Japanese Red Cross Ishinomaki Hospital, Ishinomaki, Miyagi, Japan.

Respiratory investigation

|January 25, 2026

要旨

Background:

Skeletal muscle dysfunction frequently accompanies chronic obstructive pulmonary disease (COPD). Handgrip strength (HGS) is a simple, reliable measure of muscle strength. This study aimed to evaluate its prognostic significance in COPD.

Methods:

We conducted a prospective observational study in a cohort of Japanese patients with COPD, stratified by HGS. Patient characteristics, exacerbations, and mortality were evaluated over 5 years. Low HGS was defined as <28 kg in men and <18 kg in women.

Results:

Among 300 patients, 89 (29.7 %) had low HGS. Compared with patients with normal HGS, these patients had a lower body mass index, worse pulmonary function, more severe dyspnea, poorer health status, and reduced physical activity. Exacerbation rates were similar between the groups. Low HGS was associated with an increased risk of all-cause mortality (hazard ratio, 1.79; 95 % confidence interval, 1.03-3.13).

Conclusions:

Low HGS was associated with adverse clinical outcomes in Japanese patients with COPD.

キーワード:

慢性閉塞性肺疾患増悪手の握力死亡率筋力低下

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