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Updated: Jan 27, 2026

Author Spotlight: A Personalized Approach Towards Investigating Alzheimer's Disease Using an In Vitro Blood-Brain Barrier Model

Author Spotlight: A Personalized Approach Towards Investigating Alzheimer's Disease Using an In Vitro Blood-Brain Barrier Model

Published on: October 20, 2023

神経変性疾患におけるミグロソームのメカニズムと治療の可能性

Simeng Zhang¹, Yanhua Yang¹, Tiancheng Zhang¹

¹School of Life Sciences, Jiangsu University, Zhenjiang 212013, PR China.

Cellular signalling

|January 25, 2026

Abstract:

Migrasomes, a recently identified class of organelles, form at the tips or intersections of retraction fibers during cell migration. These structures carry various bioactive cargoes, including proteins, mRNAs, and cytokines, and play significant roles in intercellular communication, immune regulation, and tissue homeostasis. As specialized membrane structures generated during cell migration, migrasomes are not only involved in physiological processes such as embryonic development and vascular homeostasis but are also critically implicated in the pathogenesis of neurological disorders. In this review, we outline the fundamental biological characteristics and functions of migrasomes, provide an in-depth analysis of their pathological mechanisms in neurological diseases, and evaluate their clinical potential as novel diagnostic biomarkers, drug delivery vehicles, and therapeutic targets. Overall, this review offers new perspectives for precision diagnostics and therapeutics of neurological diseases and lays a foundation for diagnosing and treating migrasome-related pathologies.

キーワード:

ミグロソーム神経変性疾患病態メカニズム治療標的

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