カリフォルニア州における脳卒中治療システム：機械的血栓回収療法の時代における組織編成の変遷

Optimized stroke systems of care enable access to timely care, including endovascular thrombectomy (EVT). Stroke systems have likely evolved after publication of EVT benefit (2015). Our objective was to map the stroke patient transfer network in California in terms of EVT access and patient transfer patterns, and to examine changes after 2015.

In this observational study, we identified all ischemic stroke encounters, transfers, alteplase use, and EVT procedures in California from 2010 to 2017. An established connection between any hospital pair was defined as the transfer of ≥2 patients between them. A 2-level logistic regression model assessed whether encounters were more frequently transferred to EVT-capable hospitals post-2015, adjusting for patient- and hospital-level factors. Linear regression examined trends in key network characteristics over time, and interrupted time series regressions examined for changes post-2015.

Among 336 247 encounters, 3.4% were transferred, 9.3% received alteplase, and 2.3% underwent EVT. From 2010 to 2017 the proportion that were EVT treated increased (1.0%-4.3%; P-for-trend<0.001) with a significant increase post-2015 (P=0.01). Odds of transfer to EVT-capable hospital were greater post-2015 (adjusted odds ratio, 6.54; [95% CI 5.52-7.74]), but were lower for patients who were older, Black, Hispanic, and presented to a rural hospital. Significant network changes from 2010 to 2017 included increased number of encounters transferred, increased number of transferring hospitals, decreasing number of receiving hospitals, and increased proportion of receiving hospitals performing EVT. However, none of these network changes demonstrated a significant inflection point after 2015.

The California stroke network has been dynamic over time. Although most changes have been incremental, after the release of EVT trial data in 2015 changes in transfer patterns did lead to increased access to EVT.