Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Entropy02:39

Entropy

35.4K
Salt particles that have dissolved in water never spontaneously come back together in solution to reform solid particles. Moreover, a gas that has expanded in a vacuum remains dispersed and never spontaneously reassembles. The unidirectional nature of these phenomena is the result of a thermodynamic state function called entropy (S). Entropy is the measure of the extent to which the energy is dispersed throughout a system, or in other words, it is proportional to the degree of disorder of a...
35.4K
Entropy01:18

Entropy

3.6K
The first law of thermodynamics is quantitatively formulated via an equation relating the internal energy of a system, the heat exchanged by it, and the work done on it. A quantitative formulation of the second law of thermodynamics leads to defining a state function, the entropy.
When an ideal gas expands isothermally, the disorder in the gas increases. From the molecular perspective, the gas molecules have more volume to move around in.
Consider an infinitesimal step in the expansion, which...
3.6K
Standard Entropy Change for a Reaction03:00

Standard Entropy Change for a Reaction

24.2K
Entropy is a state function, so the standard entropy change for a chemical reaction (ΔS°rxn) can be calculated from the difference in standard entropy between the products and the reactants.
24.2K
Entropy and Solvation02:05

Entropy and Solvation

8.4K
The process of surrounding a solute with solvent is called solvation. It involves evenly distributing the solute within the solvent. The rule of thumb for determining a solvent for a given compound is that like dissolves like. A good solvent has molecular characteristics similar to those of the compound to be dissolved. For example, polar solutions dissolve polar solutes, and apolar solvents dissolve apolar solutes. A polar solvent is a solvent that has a high dielectric constant (ϵ...
8.4K
Entropy within the Cell01:22

Entropy within the Cell

12.8K
A living cell's primary tasks of obtaining, transforming, and using energy to do work may seem simple. However, the second law of thermodynamics explains why these tasks are harder than they appear. None of the energy transfers in the universe are completely efficient. In every energy transfer, some amount of energy is lost in a form that is unusable. In most cases, this form is heat energy. Thermodynamically, heat energy is defined as the energy transferred from one system to another that...
12.8K
Entropy and the Second Law of Thermodynamics01:20

Entropy and the Second Law of Thermodynamics

4.9K
The second law of thermodynamics can be stated quantitatively using the concept of entropy. Entropy is the measure of disorder of the system.
The relation  between entropy and disorder can be illustrated with the example of the phase change of ice to water. In ice, the molecules are located at specific sites giving a solid state, whereas, in a liquid form, these molecules are much freer to move. The molecular arrangement has therefore become more randomized. Although the change in average...
4.9K

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Food formulation: rheological and tribological determinants of oral processing and flavor perception.

Food research international (Ottawa, Ont.)·2026
Same author

Dietary isothiocyanates inhibit the oxidative activity of salivary aldehyde dehydrogenase ALDH3A1 and modulate aroma release.

Food chemistry·2026
Same author

A Human Oral Bacterial β-Glucosidase Involved in Aroma Release from Glycosides.

Journal of agricultural and food chemistry·2026
Same author

Odour learning concentration influences concentration range of conditioned response in newborn rabbits.

Scientific reports·2025
Same author

Nasal xenobiotic metabolizing enzymes: at the crossroads of toxicity, detoxification, and olfaction.

Chemical senses·2025
Same author

Investigating the influence of astringent compounds on oral lubrication and the protective role of proline-rich proteins.

Scientific reports·2025
Same journal

Enhanced and selective oxygen reduction by iron porphyrin with a biguanide residue in the second coordination sphere.

Chemical science·2026
Same journal

Excited-state orbital angular momentum enables all-optical molecular spin coherence.

Chemical science·2026
Same journal

Polyvinyl-based hole-transporting materials processed with non-destructive and green solvents for tin-lead perovskite solar cells and all-perovskite tandems.

Chemical science·2026
Same journal

Pd-catalyzed regio- and enantioselective allylation of cyclic allylboronates.

Chemical science·2026
Same journal

Covalent polyoxometalate-polyimide hybridization: multi-scale molecular engineering toward high-performance sodium-ion battery anodes.

Chemical science·2026
Same journal

Catalytic visible light-driven alkane dehydrogenation by a di-uranyl germanotungstate.

Chemical science·2026
関連記事をすべて見る

関連する実験動画

Updated: Jan 28, 2026

Localization of SUMO-modified Proteins Using Fluorescent Sumo-trapping Proteins
06:23

Localization of SUMO-modified Proteins Using Fluorescent Sumo-trapping Proteins

Published on: April 27, 2019

8.9K

タンパク質の局所エントロピー

Patrick Senet1, Adrien Guzzo2, Patrice Delarue1

  • 1Laboratoire Interdisciplinaire Carnot de Bourgogne ICB, UMR 6303, Université Bourgogne Europe, CNRS F-21000 Dijon France psenet@ube.fr +33 (0)3 80396132 +33 (0)3 80396130.

Chemical science
|January 26, 2026
PubMed
まとめ
この要約は機械生成です。

タンパク質の構造的複雑さを定量化するために局所エントロピー指標を開発した。この手法は、温度と変異がタンパク質のダイナミクスと構造アンサンブルをどのように変化させるかを明らかにする。

キーワード:
局所エントロピータンパク質構造タンパク質ダイナミクス分子動力学シミュレーション構造的複雑さ

さらに関連する動画

Identification of Plasmodesmal Localization Sequences in Proteins In Planta
08:07

Identification of Plasmodesmal Localization Sequences in Proteins In Planta

Published on: August 15, 2017

8.7K
Applications of EEG Neuroimaging Data: Event-related Potentials, Spectral Power, and Multiscale Entropy
11:15

Applications of EEG Neuroimaging Data: Event-related Potentials, Spectral Power, and Multiscale Entropy

Published on: June 27, 2013

34.4K

関連する実験動画

Last Updated: Jan 28, 2026

Localization of SUMO-modified Proteins Using Fluorescent Sumo-trapping Proteins
06:23

Localization of SUMO-modified Proteins Using Fluorescent Sumo-trapping Proteins

Published on: April 27, 2019

8.9K
Identification of Plasmodesmal Localization Sequences in Proteins In Planta
08:07

Identification of Plasmodesmal Localization Sequences in Proteins In Planta

Published on: August 15, 2017

8.7K
Applications of EEG Neuroimaging Data: Event-related Potentials, Spectral Power, and Multiscale Entropy
11:15

Applications of EEG Neuroimaging Data: Event-related Potentials, Spectral Power, and Multiscale Entropy

Published on: June 27, 2013

34.4K

科学分野:

  • タンパク質ダイナミクスと構造生物学
  • 計算生物物理学

背景:

  • タンパク質は動的なアンサンブルとして存在するが、温度と変異がこれらのアンサンブルにどのように影響するかはよく理解されていない。
  • タンパク質のゆらぎを測定する既存の方法には限界がある。

研究 の 目的:

  • タンパク質の構造的複雑さを定量化するための新しい局所エントロピー指標を導入する。
  • 温度と変異がタンパク質の構造アンサンブルに与える影響を調査する。

主な方法:

  • シャノンエントロピーとグラフから誘導されるアクセス可能な部分状態に基づいて局所エントロピー指標を開発した。
  • gpWタンパク質とα-シヌクレインの分子動力学シミュレーションを利用した。
  • 残基ごとのエントロピー曲線を取得し、他のゆらぎ尺度と比較した。

主要な成果:

  • 局所エントロピーは、gpWタンパク質の融点付近で急激な遷移を示す。
  • 残基ごとのエントロピーは、空間スケールに依存した明確なほどけパターンを明らかにする。
  • 局所エントロピーは、アクセス可能な体積やパッキングエントロピーとは異なるユニークな特徴を捉える。
  • α-シヌクレインのパーキンソン病変異は局所エントロピーを低下させ、遠隔領域を摂動させる。

結論:

  • 局所エントロピーは、様々なタンパク質状態にわたる構造的複雑さの連続的な尺度を提供する。
  • この指標は、温度と変異による構造アンサンブルの再構築を捉える。
  • 局所エントロピーはNMR観測量と相関し、タンパク質の無秩序を定量化するための一般化可能なフレームワークを提供する。