悪性尿路閉塞に対する小線源療法ステントと従来のプラスチックステントの比較：初期経験

Yipu Li¹, Chengzhi Zhang¹, Mengyao Song¹

¹Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.

Frontiers in oncology

|January 26, 2026

要旨

Objective:

To evaluate the feasibility of a newly designed integrated plastic stent loaded with radioactive ¹²⁵I seeds (brachytherapy stent) for the treatment of malignant ureteral obstruction (MUO).

Methods:

From May 2018 to May 2023, 30 patients with MUO underwent brachytherapy plastic stent placement (experimental group), while 41 patients underwent conventional plastic stent placement (control group). The primary endpoints were technical success, complications, the local disease response rate (DRR) and the gross haematuria control (GHC) rate; the secondary endpoints were the hydronephrosis Girignon score (HGC) and overall survival (OS).

Results:

The rates of technical success (100% vs. 100%), complications (26.7% vs. 14.6%) and HGC (1.5 ± 0.5) vs. (1.5 ± 0.5) in the experimental and control groups were not significantly different (p>0.05). The DRR (93.3% vs. 9.8%) and GHC rates (84.2% vs. 20.8%) of the experimental and control groups at 8 weeks were statistically significant (P<0.05). The OS [28.4 month (95% CI: 24.6-32.3) vs. 19.5 month (95% CI: 17.0-22.0)] of the experimental and control groups was significantly different (P<0.05).

Conclusion:

This novel brachytherapy stent is safe and effective for the treatment of MUO, but long term follow up is needed.

キーワード:

¹²⁵Iシード小線源療法インターベンショナルラジオロジー悪性尿路閉塞ステント

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