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未治療の全般性不安障害における安静時機能的結合の異常：全脳探索的fMRI研究
Yujing Jin1, Tong Zhang1, Wujianwen Zhai1
1Traditional Chinese Medicine Research and Development Center, Guang'anmen Hospital, Beijing, China.
Frontiers in psychiatry
|January 26, 2026
まとめ
未治療の全般性不安障害（GAD）では、脳の結合性の異常、特に後部帯状皮質と角回下回の間の結合性の異常が見られる。これらの変化は不安の重症度と相関しており、GADにおける内受容感覚処理の役割を示唆している。
科学分野:
- 神経科学
- 精神医学
- 医用画像処理
背景:
- 全般性不安障害（GAD）は、過度の心配と身体症状を特徴とする。
- 以前の神経画像研究では治療中の患者が多く含まれており、未治療のGADの理解を制限していた。
- 本研究は、未治療のGAD患者における安静時機能的結合（rsFC）に焦点を当てる。
主な方法:
- 未治療のGAD患者（n=85）と健常対照群（HC、n=82）を比較する横断研究。
- シーメンス3.0Tスキャナーを使用した安静時機能的磁気共鳴画像法（rs-fMRI）データの取得。
- 138の関心領域間の結合の、CONNツールボックスを用いた全脳、データ駆動型解析。
結論:
- 未治療のGAD患者は、特にPCC-SMGネットワークを含む、明確なrsFC異常を示す。
- PCC-SMGのrsFCの亢進は不安の重症度と相関しており、GADにおける内受容感覚過敏症の潜在的な役割を示唆している。
- 本研究結果は、SMG駆動型の警戒が不安を永続させるというモデルを支持し、介入のための潜在的な神経標的を強調する。
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