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関連する概念動画

Physiology of the Genitourinary System II: Tubular Reabsorption and Secretion01:22

Physiology of the Genitourinary System II: Tubular Reabsorption and Secretion

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The kidneys maintain homeostasis through filtration, reabsorption, and secretion. Tubular reabsorption and secretion are crucial in forming urine and regulating electrolytes, water balance, and waste elimination.Tubular Reabsorption and Secretion ProcessesTubular reabsorption is the process that reclaims essential substances such as electrolytes, glucose, amino acids, and water from the glomerular filtrate back into the bloodstream. This is achieved through passive and active transport...
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Fixed Action Patterns01:06

Fixed Action Patterns

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A fixed action pattern (FAP) is a specific, hard-wired sequence of behaviors that occurs in response to an external stimulus, called a sign stimulus. The behavior is “fixed” because it is essentially unchangeable—proceeding similarly across individuals of a species every time it occurs.
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Extraction: Advanced Methods00:56

Extraction: Advanced Methods

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Metal ions can be separated from one another by complexation with organic ligands–the chelating agent– to form uncharged chelates. Here, the chelating agent must contain hydrophobic groups and behave as a weak acid, losing a proton to bind with the metal. Since most organic ligands used in this process are insoluble or undergo oxidation in the aqueous phase, the chelating agent is initially added to the organic phase and extracted into the aqueous phase. The metal-ligand complex is...
1.1K
Overview of Advanced Functional Groups02:22

Overview of Advanced Functional Groups

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Functional groups are groups of atoms with specific chemical properties that occur within organic molecules and are sometimes denoted as “R”. Functional groups can “functionalize” a compound by enabling it to adopt different physical and chemical properties.
Types of Advanced Functional Groups
The table below summarizes some of the major functional groups in organic chemistry.
29.7K
Physiological Barriers01:25

Physiological Barriers

5.2K
Physiological barriers are semi-permeable cellular structures restricting drug diffusion into intracellular compartments and tissues. There are six types of physiological barriers: blood endothelial, cell membrane, blood-brain, blood-cerebrospinal fluid (CSF), blood-placenta, and blood-testis barriers.
The blood endothelial barrier is the most porous of these. It allows all small ionized, un-ionized, and lipophilic molecules to pass through the endothelial lining into the interstitial space...
5.2K
Hormones Secreted by the Stomach01:25

Hormones Secreted by the Stomach

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Enteroendocrine cells, accounting for only 1% of stomach epithelial cells, play a significant role in digestion and are classified by their digestive hormone secretions.
Each of these hormones secreted by different enteroendocrine cells plays a unique role in digestion. Here are a few examples:
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関連する実験動画

Updated: Jan 28, 2026

Combining Human Organoids and Organ-on-a-Chip Technology to Model Intestinal Region-Specific Functionality
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Combining Human Organoids and Organ-on-a-Chip Technology to Model Intestinal Region-Specific Functionality

Published on: May 5, 2022

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生理学的細胞複雑性を持つ高度なヒトオルガノイドオンチップが双方向分泌パターンを明らかにする

Inga Viktoria Hensel1,2, Szabolcs Éliás1, Michelle Steinhauer1

  • 1BioMed X Institute, Heidelberg 69120, Germany.

iScience
|January 26, 2026
PubMed
まとめ

上皮細胞が腸管免疫をどのように管理するかを研究するために、ヒト腸オルガノイドオンチップモデルを開発しました。この高度なプラットフォームは、細胞固有の刺激に対する応答を明らかにし、腸管バリア機能の理解と新しい治療法の開発を支援します。

背景:

  • 腸上皮細胞は重要なバリアを形成し、非対称分泌を通じて免疫応答を調節します。
  • 上皮細胞タイプと刺激がこの分泌にどのように影響するかを理解することは、腸管の恒常性にとって不可欠です。
  • 既存のモデルでは、in vivoのヒト腸管生理機能を完全に再現するのに十分な複雑性が欠けています。

結論:

  • 開発されたOoCモデルは、ヒト腸上皮バリア機能を研究するための強力なプラットフォームです。
キーワード:
生物科学生物医学工学免疫学

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  • このモデルは、生理学的および病理生理学的条件下での上皮細胞媒介の自然免疫に関する洞察を提供します。
  • OoCシステムは、腸関連疾患の個別化治療戦略を進歩させる可能性を提供します。