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Updated: Jan 28, 2026

Utilizing Repetitive Transcranial Magnetic Stimulation to Improve Language Function in Stroke Patients with Chronic Non-fluent Aphasia

Utilizing Repetitive Transcranial Magnetic Stimulation to Improve Language Function in Stroke Patients with Chronic Non-fluent Aphasia

Published on: July 2, 2013

脳卒中生存者における上肢運動機能に対する反復経頭蓋磁気刺激の効果：ランダム化シャム対照試験の試験プロトコル

Tao Sun^1,2, Qian Yu^1,2

¹Department of Rehabilitation, Affiliated Hospital of Southwest Medical University, Luzhou, China.

Frontiers in neurology

|January 26, 2026

要旨

Background:

Stroke is a group of diseases with neurological deficits caused by cerebrovascular lesions. Despite standard treatment, a large number of patients are left with significant upper extremity motor dysfunction. Therefore, improving upper limb motor function and promoting neurological recovery in stroke patients has become a core challenge in the field of neurorehabilitation.

Methods And Analysis:

This study will be designed as a randomized, sham controlled clinical trial. Thirty-six patients with upper limb motor dysfunction after stroke will be included, and their Fugl-Meyer Upper Extremity Motor Function Rating Scale (FMA-UE) score will be ≤ 26 points. Subjects will be randomly assigned to the following three groups (n = 12/group): HF-rTMS: Treated with high-frequency (5 Hz) repetitive transcranial magnetic stimulation (rTMS) on the dorsal premotor cortex (PMd) on the contralesional side. Low-frequency group (LF-rTMS): Treated with low-frequency (1 Hz) rTMS on the primary motor cortex (M1) on the contralesional side. Sham control group: The stimulation target and parameter settings will be the same as those of the high-frequency group, but the coil will be placed perpendicular to the scalp plane. The intervention regimen will be rTMS treatment once daily, five times a week for 3 weeks. Outcome measures: Main outcome measures: Upper limb motor function, assessed by FMA-UE. Secondary outcomes: Barthel Index (BI), National Institutes of Health Stroke Scale (NIHSS). Exploratory indicators: fMRI data and motor evoked potential (MEP) parameters. All assessment data will be collected before and after the intervention.

Communication And Ethics:

This study has been reviewed and approved by the Basic and Clinical Research Ethics Committee of Sichuan Provincial People's Hospital (Lun Shen (Yan) No. 353-1 of 2025). The results of this research will be disseminated through the network of professionals and the general public, and peer-reviewed scientific papers will be published and presented at relevant conferences.

Registration:

This trial has been registered with the Chinese Clinical Trials Registry with registration number ChiCTR2500105502.

キーワード:

非麻痺側の背側運動前野機能的磁気共鳴画像法高頻度反復経頭蓋磁気刺激運動誘発電位シャム対照脳卒中

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