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Updated: Aug 18, 2026

A Revised Method for Inducing Secondary Lymphedema in the Hindlimb of Mice
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Published on: November 2, 2019

"UPARAPをターゲットにすることで,リンパ管の構造が変化し,リンパ腫が軽減される"という記事に関するRan et alの手紙

Qingzhi Ran1, Yongkang Zhang2, Hengwen Chen1

  • 1Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China (Q.R., H.C.).

Circulation
|January 26, 2026
PubMed
まとめ

No abstract available in PubMed .

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Endothelins (ETs) are potent vasoactive peptides critical in the human body's various physiological and pathological processes. One of the most promising therapeutic strategies for treating pulmonary arterial hypertension (PAH) involves counteracting the effects of these endothelins using a class of drugs known as endothelin receptor antagonists.
ETs are synthesized through a complex sequence of enzymatic steps, primarily involving an enzyme referred to as endothelin-converting enzyme (ECE). Of...