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Updated: Jan 28, 2026

Synthesis and Characterization of 1,2-Dithiolane Modified Self-Assembling Peptides

Synthesis and Characterization of 1,2-Dithiolane Modified Self-Assembling Peptides

Published on: August 20, 2018

ペプチド合成に向けた直交電気化学的アミン脱保護：持続可能な戦略に向けて

Esteban Suárez-Picado¹, Saurabh K Ahirwar¹, Lara R Malins¹

¹Research School of Chemistry and Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, Australian National University, Canberra, ACT 2601, Australia.

Organic letters

|January 26, 2026

Abstract:

Deprotection steps employed in peptide synthesis often require harsh conditions and excess reagents, limiting substrate compatibility and sustainability. Electrochemically cleavable protecting groups (e-PGs) offer an attractive alternative. Here, we report the use of 1,3-dithiane-based e-PGs for orthogonal protection of lysine ε-amines in peptide synthesis. Under constant potential electrolysis, deprotection proceeds selectively and orthogonally to other common amino acid protecting groups (Alloc, Boc, Dde, Fmoc, Trt, Pbf, tBu), highlighting potential applications in sustainable peptide synthesis.

キーワード:

電気化学的脱保護ペプチド合成保護基リジン持続可能な化学

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