アフェレーシス製剤に匹敵する価値のあるプールされた顆粒球成分か?
Artur Szumowski1, Tomasz Wasiluk2, Magdalena Średzińska2
1Department of Hematology, Internal Medicine and Angiology with Hematopoietic Cell Transplantation Unit, Medical University of Bialystok, Bialystok, Poland; Regional Centre for Transfusion Medicine in Bialystok, Bialystok, Poland.
Advances in medical sciences
|January 26, 2026
まとめ
顆粒球濃縮物(GC)の調製方法の違いは、細胞数と生存率に影響を与える。ガンマ線照射と保管は品質を低下させるが、プールされたGCは臨床使用に実行可能な選択肢である。
科学分野:
- 血液学、輸血医学、細胞療法
背景:
- 顆粒球濃縮物(GC)は、血液悪性腫瘍を有する好中球減少症患者の感染症管理に不可欠である。GCの品質を最適化するためには、収集および調製方法の評価が重要である。
主な方法:
- 白血球除去(L)、バフィーコートのプール(S)、またはReveos(R)を使用して30個のGCを収集した。ガンマ線で照射し、室温で24時間保管した。白血球(WBC)、好中球、リンパ球、単球数、pH、細胞生存率、食作用、およびCD11b、CD62L、CD66b、CXCR4の発現を評価した。
結論:
- アフェレーシス由来およびプールされたGCは同等の品質を示し、プールされたGCの使用増加を示唆している。ガンマ線照射は顆粒球成分の品質に悪影響を与えない。最適な治療効果を得るためには、新鮮に収集されたGCを優先することが推奨される。
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