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Lung Capacity01:47

Lung Capacity

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The air in the lungs is measured in volumes and capacities. Lung volume measures reflect the amount of air taken in, released, or left over after a lung function, like a single inhalation. Lung capacity measures are sums of two or more lung volume measures.
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Toxic Reactions: Overview01:26

Toxic Reactions: Overview

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When toxic substances penetrate the human body, they disseminate to various tissues, undergoing metabolic changes. This process yields reactive metabolites that may covalently bind with specific target molecules, resulting in toxicity.
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
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Pleura of the Lungs01:13

Pleura of the Lungs

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The lungs are nestled in a cavity, shielded by the pleura. The pleura, a form of serous membrane, wraps around each lung. This membrane arrangement consists of two layers: the visceral and parietal pleurae. The visceral pleura lines the surface of the lungIn contrast, the parietal pleura is the outer layer and contacts to the thoracic wall, the mediastinum, and the diaphragm. The hilum is the point of connection between the visceral and parietal layers. The space between the parietal and...
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Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

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Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
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Gross Anatomy of the Lungs01:17

Gross Anatomy of the Lungs

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The lungs are a pair of vital organs connected to the trachea via the left and right bronchi. The base of these organs meets the dome-shaped muscle known as the diaphragm. Encased by the pleurae, the lungs contact the mediastinum. The right lung is shorter yet wider, and has a larger volume than the left lung. The left lung has an indentation known as the cardiac notch. The superior region of the lungs is referred to as the apex, whereas the base is the lower region near the diaphragm. The...
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Immunodeficiency Diseases01:25

Immunodeficiency Diseases

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Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
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Updated: Jan 28, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
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Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

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牛における中毒性間質性肺疾患

Claudio S L Barros1, Franklin Riet-Correa2, Ricardo E Mendes3

  • 1Laboratory of Anatomic Pathology, School of Veterinary Medicine and Animal Sciences, Federal University of Mato Grosso do Sul, Campo Grande, MS, Brazil.

Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
|January 27, 2026
PubMed
まとめ

有毒物質は牛の間質性肺疾患を引き起こし、間質性肺炎につながります。診断には、L-トリプトファン、4-イポメアノール、有毒植物、二酸化窒素などの毒素への曝露の調査が必要です。

キーワード:
ウシ間質性肺疾患間質性肺炎肺毒性物質

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Protocol and Guidelines for Point-of-Care Lung Ultrasound in Diagnosing Neonatal Pulmonary Diseases Based on International Expert Consensus
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Protocol and Guidelines for Point-of-Care Lung Ultrasound in Diagnosing Neonatal Pulmonary Diseases Based on International Expert Consensus

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Assessment of the Cytotoxic and Immunomodulatory Effects of Substances in Human Precision-cut Lung Slices
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Protocol and Guidelines for Point-of-Care Lung Ultrasound in Diagnosing Neonatal Pulmonary Diseases Based on International Expert Consensus
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Assessment of the Cytotoxic and Immunomodulatory Effects of Substances in Human Precision-cut Lung Slices
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科学分野:

  • 獣医病理学
  • 毒物学
  • 肺医学

背景:

  • 牛の間質性肺疾患（ILD）は、肺胞壁および細気管支間質の病変を含む。
  • 有毒物質は牛の間質性肺疾患の重要な原因であり、しばしば間質性肺炎として現れる。

研究 の 目的:

  • 牛の間質性肺疾患を引き起こす主要な物質をレビューすること。
  • これらの毒素に関連する疫学、臨床兆候、病原性、病変について議論すること。

主な方法:

  • 牛の間質性肺疾患を引き起こす有毒物質に関する文献レビュー。
  • 疫学データ、臨床所見、病理学的所見の分析。
  • 診断上の課題と限界についての議論。

主要な成果:

  • 主要な毒素を特定した：L-トリプトファン、4-イポメアノール、有毒植物（Perilla frutescens、Zieria arborescens）、二酸化窒素（NO2）。
  • 診断を複雑にする、重複する臨床兆候と病変を強調した。
  • 毒素の急速な代謝のため、実験室での確認が困難であることを強調した。

結論:

  • 牛における中毒性間質性肺疾患の確定診断は、徹底的な疫学的調査と曝露の確認に大きく依存する。
  • 予防と管理のためには、特定の毒素とその発生源を理解することが重要である。
  • 不安定な毒素の診断方法を改善するためには、さらなる研究が必要となる可能性がある。